Toward wearable patch for sweat analysis
Toward wearable patch for sweat analysis
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DOI：
10.1016/j.snb.2016.01.143
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发表时间：
2016-11-29
影响因子：
8.4
通讯作者：
van Schaijk, R.
中科院分区：
文献类型：
--
作者：
Dam, V. A. T.;Zevenbergen, M. A. G.;van Schaijk, R.
本工作介绍了一种廉价的一次性小型化电化学传感平台，该平台是在聚对苯二甲酸乙二醇酯衬底上制作的，用于连续监测汗液中的离子组成。该汗片由汗液收集区域、集成参比电极和用于实时监测汗液中氯离子浓度的丝网印刷氯化银电极阵列组成。优化了AgCl电极的印刷工艺和厚度，提高了电极在流体中的稳定性。氯化银电极在液体中稳定一周以上，氯离子灵敏度为58 mV/10。通过在阵列中的一个AgCl电极上添加一层聚甲基丙烯酸羟乙酯水凝胶层，然后在3MKCl溶液中进行处理，在同一贴片上成功地制备了参比电极。这种贴片戴在受试者的胸前，能够在一小时的跑步机运动中连续监测受试者汗液中的氯离子浓度。从受试者身上采集并离线分析的汗液样本的实时测量和控制测量之间显示出合理的一致性。(C)2016爱思唯尔B.V.保留所有权利。
This work presents an inexpensive and disposable miniaturized electrochemical sensing platform, which was fabricated on a polyethylene terephthalate substrate for continuously monitoring the ion composition of sweat. The sweat patch consisted of an area for sweat collection, integrated reference electrode and an array of screen printed AgCl electrodes for real-time monitoring chloride concentration in sweat. The printing process and thickness of the AgCl electrodes were optimized to enhance the stability of the electrode in fluid. The AgCl electrodes were stable for more than a week in fluid and had a chloride sensitivity of 58 mV per decade. The reference electrode was successfully fabricated on the same patch by adding a polyhydroxyethylmethacrylate hydrogel layer on top of one of the AgCl electrode in the array and followed by conditioning in 3 M KCl solution. The patch, which was worn on the chest of a test subject, was able to continuously monitor the chloride concentration in sweat of the test subject during an one hour treadmill exercise. Reasonable agreement was shown between the real-time measurements and control measurements of sweat samples, which were collected from the test subject and analyzed off-line. (C) 2016 Elsevier B.V. All rights reserved.