Effects of sex hormones on fulminant hepatitis in LEC rats: a model of Wilson's disease.
Effects of sex hormones on fulminant hepatitis in LEC rats: a model of Wilson's disease.
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性激素对 LEC 大鼠暴发性肝炎的影响：威尔逊病模型。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
Yoshida Mc
中科院分区：
文献类型：
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作者：
Noriyuki Kasai;I. Miyoshi;T. Osanai;Tadashi Yamashita;E. Kamimura;Yoshida Mc
LEC大鼠患有遗传性肝炎，最近被提议作为威尔逊病的动物模型，研究了性激素对暴发性肝炎的影响。切除卵巢或睾丸（去势）的大鼠与未切除卵巢的大鼠相比，发病年龄没有明显改变，但雌性的存活率从50%下降到12.5%，雄性的存活率从75%下降到14.3%，表明性激素不影响暴发性肝炎的发生，但影响暴发性肝炎的死亡率。当给去卵巢或去兰花的大鼠注射睾酮时，两性的存活率都提高到90%以上。相比之下，雌二醇不影响任何性别的存活率，但影响暴发性肝炎的发病。也就是说，给雌二醇后，去卵巢大鼠的血清GPT活性达到最大值的年龄比未受影响的大鼠推迟了4周，去兰花大鼠的血清GPT活性达到最大值的年龄比正常大鼠推迟了6周。给黄体酮的大鼠也出现了类似但稍弱的倾向。我们的研究结果表明性激素对肝炎的发生率没有影响，但影响肝炎的进展。特别是，睾酮增加了暴发性肝炎大鼠的存活率，外源性雌二醇将肝炎的发病延迟数周。
LEC rats, which have hereditary hepatitis and have recently been proposed as an animal model for Wilson's disease, were examined to determine the effects of sex hormones on fulminant hepatitis. After the rats had undergone ovariectomies or orchidectomies (castration) and were compared with intact rats, the age at the onset of fulminant hepatitis was not substantially altered but the survival rates decreased from 50% to 12.5% for females and 75% to 14.3% for males, indicating that sex hormones did not influence the occurrence of fulminant hepatitis but influenced mortality due to fulminant hepatitis. When testosterone was administered to the ovariectomized or orchidectomized rats, the survival rate increased to over 90% in both sexes. In contrast, estradiol did not affect the survival rate of either sex but affected the onset of fulminant hepatitis. That is, with the administration of estradiol, the age at which serum GPT activity reached its maximum was delayed 4 weeks in ovariectomized rats and 6 weeks in orchidectomized rats as compared with intact rats. A similar but somewhat weaker tendency appeared in rats given progesterone. The results of our study indicate that sex hormones have no effect on the rate of occurrence of hepatitis but affect the progression of hepatitis. In particular, testosterone increased the survival rate of rats with fulminant hepatitis, and exogenous estradiol delayed the onset of hepatitis for several weeks.