Synthesis of fused bicyclic imidazoles by sequential van Leusen/ring-closing metathesis reactions
Synthesis of fused bicyclic imidazoles by sequential van Leusen/ring-closing metathesis reactions
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DOI：
10.1021/ol050852
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发表时间：
2005-07-21
期刊：
影响因子：
5.2
通讯作者：
Djuric, SW
中科院分区：
文献类型：
--
作者：
Gracias, V;Gasiecki, AF;Djuric, SW
采用货车Leusen三组分反应和闭环复分解反应的顺序方式获得稠合双环咪唑环的新策略。两步序列产生的化合物的显着分子复杂性从简单的起始材料在一个方便的方式具有优异的产率。
A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.