Genomic analysis of the host response to hepatitis B virus infection
Genomic analysis of the host response to hepatitis B virus infection
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DOI：
10.1073/pnas.0401771101
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发表时间：
2004-04-27
影响因子：
11.1
通讯作者：
Chisari, FV
中科院分区：
文献类型：
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作者：
Wieland, S;Thimme, R;Chisari, FV
先前对感染B型肝炎病毒（HBV）的人类和黑猩猩的研究表明，HBV感染的控制涉及免疫应答的细胞、效应器功能和分子介质。本研究的目的是确定，在急性HBV感染的黑猩猩的肝脏中，病毒诱导的和免疫反应相关的基因调控感染的谱。结果表明，HBV在进入和扩增过程中不诱导任何基因，表明它是感染早期的隐形病毒。相反，在病毒清除过程中，大量T细胞衍生的IFN-γ调节基因在肝脏中被诱导，反映了抑制病毒复制并杀死感染细胞的适应性T细胞应答的影响，从而终止感染。
Previous studies in hepatitis B virus (HBV)-infected humans and chimpanzees suggest that control of HBV infection involves the cells, effector functions, and molecular mediators of the immune response. The objective of the current study was to identify, in the liver of acutely HBV-infected chimpanzees, the spectrum of virus-induced and immune response-related genes that regulate the infection. The results demonstrate that HBV does not induce any genes during entry and expansion, suggesting it is a stealth virus early in the infection. In contrast, a large number of T cell-derived IFN-gamma-regulated genes are induced in the liver during viral clearance, reflecting the impact of an adaptive T cell response that inhibits viral replication and kills infected cells, thereby terminating the infection.