CD13 regulation of membrane recycling: implications for cancer dissemination.
CD13 regulation of membrane recycling: implications for cancer dissemination.
复制标题
CD13 膜回收调节：对癌症传播的影响。
DOI：
10.1080/23723556.2019.1648024
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发表时间：
2019
影响因子：
2.1
通讯作者：
Shapiro,LindaH
中科院分区：
文献类型：
--
作者：
Ghosh,Mallika;Shapiro,LindaH
膜再循环对许多细胞功能至关重要，其失调有助于癌症和转移。我们确定跨膜分子氨肽酶N（ANPEP，也称为CD 13）的激活将含有IQ基序的三磷酸鸟苷水解酶激活蛋白1（IQGAP 1）支架蛋白拴在质膜上，从而刺激再循环调节因子ADP-核糖基化因子6（ARF 6），以确保β1-整联蛋白和其他影响细胞附着的膜组分的适当再循环。
Membrane recycling is critical to numerous cell functions and its dysregulation contributes to cancer and metastasis. We established that activation of the transmembrane molecule aminopeptidase N (ANPEP, also known as CD13) tethers the IQ motif containing, guanosine triphosphate hydrolase activating protein 1 (IQGAP1) scaffolding protein at the plasma membrane, thus stimulating the recycling regulator ADP-ribosylation factor 6 (ARF6) to ensure proper recycling of β1-integrin and other membrane components impacting cell attachment.