Testican 3 expression in adult T-cell leukemia
Testican 3 expression in adult T-cell leukemia
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DOI：
10.1016/j.leukres.2008.11.006
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发表时间：
2009-07-01
影响因子：
2.7
通讯作者：
Sugiura, Tetsuro
中科院分区：
文献类型：
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作者：
Kamioka, Mikio;Imamura, Jun;Sugiura, Tetsuro
成人T细胞白血病(ATL)是一种以内脏侵袭为特征的侵袭性疾病，ATL调节内皮细胞的基质金属蛋白酶(MMPs)活性。ATL中基质金属蛋白酶活性的调控系统受多种因素的调控，如Emmprin、基质金属蛋白酶组织抑制因子等。在本研究中，我们发现Testican3在ATL中的表达降低了基质金属蛋白酶的活性。此外，我们还发现在人类嗜T淋巴细胞病毒I型相关细胞系中，Testican 3的表达受转录因子3的激活所调节。因此，Testican 3是ATL(C)2008 Elsevier Ltd.中降低基质金属蛋白酶活性的一种新型调节剂。保留所有权利。
Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion, and ATL regulates matrix metalloproteinase (MMP) activities of the endothelial cells. The controlling system of MMP activities in ATL is regulated by various factors such as Emmprin and tissue inhibitor of MMP. In this study, we demonstrated that Testican 3 expression in ATL decreased the activity of MMP. Furthermore, we showed that the expression of Testican 3 was regulated by activating transcriptional factor 3 in human T-lymphotropic virus type I-related cell lines. Thus, Testican 3 is a novel regulator to reduce the activity of MMP in ATL (C) 2008 Elsevier Ltd. All rights reserved.