Histological and immunological features of non-eosinophilic nasal polyps
Histological and immunological features of non-eosinophilic nasal polyps
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DOI：
10.1016/j.otohns.2007.07.036
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发表时间：
2007-12-01
影响因子：
3.4
通讯作者：
Rhee, Chae-Seo
中科院分区：
文献类型：
--
作者：
Kim, Jeong-Whun;Hong, Sung-Lyong;Rhee, Chae-Seo
目的：本研究旨在探讨非嗜酸性鼻息肉（NPs）的组织免疫学特征。方法：本研究纳入30例慢性鼻-鼻窦炎和NPs患者。根据 NP 中嗜酸性粒细胞的数量，将 NP 分为嗜酸性和非嗜酸性类型。测定血清总IgE和外周血嗜酸性粒细胞的量。测量了基底膜 (BM) 厚度，以及 NP 淋巴细胞中趋化因子受体 5 (CCR5) 和趋化因子受体 3 (CCR3) 的表达。 结果：非嗜酸性 NP 占本研究纳入的 NP 总数的 66.7%。 NPs中嗜酸性粒细胞的数量与外周血嗜酸性粒细胞增多有关，但与血清IgE升高无关。非嗜酸性粒细胞的 BM 明显比嗜酸性粒细胞的 NP 薄。与嗜酸性 NP 相比，表达 CCR5 或 CCR3 的淋巴细胞在非嗜酸性 NP 中较少见。 结论：非嗜酸性 NP 的组织免疫学特征与嗜酸性 NP 不同。非嗜酸性 NP 的特征可能是 BM 较薄以及 CCR5 和 CCR3 阳性淋巴细胞较少。 (c) 2007 年美国耳鼻喉科学会-头颈外科基金会。版权所有。
OBJECTIVE: The aim of this study was to investigate the histoimmunological features of non-eosinophilic nasal polyps (NPs).METHODS: Thirty patients with chronic rhinosinusitis and NPs were included in this study. NPs were grouped into eosinophilic and non-eosinophilic types according to the amount of eosinophils in the NPs. The amount of serum total IgE and peripheral blood eosinophils were measured. Basement membrane (BM) thickness was measured, along with the expression of chemokine receptor 5 (CCR5) and chemokine receptor 3 (CCR3) in NP lymphocytes.RESULTS: Non-eosinophilic NPs comprised 66.7% of the total NPs included in this study. The amount of eosinophils in NPs was related to eosinophilia of the peripheral blood, but not to elevated serum IgE. BM was significantly thinner in non-eosinophilic than in eosinophilic NPs. Lymphocytes expressing CCR5 or CCR3 were less frequently found in non-eosinophilic than in eosinophilic NPs.CONCLUSION: Histoimmunological characteristics of non-eosinophilic NPs differ from those of eosinophilic NPs; non-eosinophilic NPs may be featured by thinner BM and fewer CCR5- and CCR3-positive lymphocytes. (c) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.