Bone Marrow Lipid Profiles from Peripheral Skeleton as Potential Biomarkers for Osteoporosis: A 1H-MR Spectroscopy Study
Bone Marrow Lipid Profiles from Peripheral Skeleton as Potential Biomarkers for Osteoporosis: A 1H-MR Spectroscopy Study
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DOI：
10.1016/j.acra.2015.11.009
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发表时间：
2016-03-01
影响因子：
4.8
通讯作者：
Tarantino, Umberto
中科院分区：
文献类型：
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作者：
Di Pietro, Giulia;Capuani, Silvia;Tarantino, Umberto
基本原理和目标：通过3 T磁共振波谱（MRS）对健康、骨质疏松和骨质疏松女性跟骨和股骨颈的骨髓进行表征。最终目标是鉴定具有区分健康、骨质疏松和骨质疏松受试者的潜在能力的特定代谢物。分别招募62名和33名绝经后妇女研究跟骨和股骨颈，进行骨矿物质密度（BMD）测量，分为健康受试者（n = 22），骨质减少（n = 45），或类风湿性关节炎（n = 28）患者。MRS谱用于量化和比较三个BMD组之间的骨髓脂肪共振。使用Welch方差分析检验组间差异。采用Games-Howell校正进行多重比较。用线性相关分析评估变量对之间的关系。结果：重复性良好。在股骨颈，亚甲基（L13），甘油（L41，L43），和总脂质共振显着低于健康相比，骨质疏松症的受试者。另一方面，在跟骨中，L13/甘油显著区分骨质疏松和骨质疏松受试者，而L13/（不饱和脂质）区分健康和骨质疏松组。然而，不饱和脂质和甘油共振的再现性不太理想。结论：MRS骨髓脂质分布从外周骨骼网站可能是一个很有前途的工具，用于筛选大的人口，以确定个人或发展为骨质疏松症的风险。此外，它还提供了有关骨质疏松症发生时骨髓中代谢变化的信息，这些变化是骨骼部位依赖性的。
Rationale and Objectives: To characterize the lipidic profile of bone marrow in the calcaneus and femoral neck of healthy, osteopenic, and osteoporotic women, by using magnetic resonance spectroscopy (MRS) at 3T. The final goal was to identify specific metabolites with the potential ability to discriminate between healthy, osteopenic, and osteoporotic subjects.Materials and Methods: Sixty-two and thirty three postmenopausal women recruited to investigate calcaneus and femoral neck, respectively, underwent a bone mineral density (BMD) measurement to be classified as healthy subjects (n = 22), osteopenic (n = 45), or osteoporotic (n = 28) patients. MRS spectra were used to quantify and compare bone marrow fat resonances between the three BMD groups. Between-group differences were tested using a Welch analysis of variance. Multiple comparisons were made with the Games-Howell correction. Relationships between pairs of variables were assessed with linear correlation analysis. Reproducibility analysis was performed for all the lipid resonances in both sites.Results: The reproducibility was satisfactory. In femoral neck, methylene (L13), glycerol (L41, L43), and total lipid resonances were significantly lower in healthy as compared to osteoporotic subjects. On the other hand, in calcaneus, L13/glycerol significantly discriminated between osteopenic and osteoporotic subjects whereas L13/(unsaturated lipid) discriminated between healthy and osteopenic group. However, the reproducibility of both unsaturated lipid and glycerol resonances were less optimal.Conclusions: MRS of bone marrow lipid profiles from peripheral skeletal sites may be a promising tool for screening of large population to identify individuals with or at risk for developing osteoporosis. Moreover, it provides information about the metabolic changes occurring in bone marrow with the development of osteoporosis, which are skeletal site dependent.