Potential value of estrogen receptor beta expression in colorectal carcinoma: interaction with apoptotic index.
Potential value of estrogen receptor beta expression in colorectal carcinoma: interaction with apoptotic index.
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DOI：
10.1007/s12029-010-9214-4
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发表时间：
2012-03-01
影响因子：
1.6
通讯作者：
Hashim, Maha Abo
中科院分区：
文献类型：
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作者：
Elbanna, Hosam Ghazy;Ebrahim, Mohamed Awad;Hashim, Maha Abo
目得：本研究旨在探讨大肠癌雌激素受体β（ER β）表达与大肠癌的临床病理学关系、与凋亡指数的关系及预后意义。前瞻性收集患者资料，以2年总生存期为终点。雌激素受体β表达通过免疫组织化学评估。结果：大肠癌雌激素受体β阳性率为65%，而雌激素受体α阳性率仅为7%。雌激素受体β免疫反应性在低级别结直肠肿瘤中的表达率显著较高。雌激素受体β阳性病例的中位凋亡指数显著高于雌激素受体β阴性病例（6%对3%; p=0.01）。雌激素受体β阳性病例的中位总生存期较高（22与18个月），然而，差异无统计学意义。结论：研究结果加强了雌激素受体β，而不是雌激素受体α在结直肠癌的重要性。雌激素受体β表达的缺乏与分化丧失和细胞凋亡减少有关。未来的研究应包括雌激素受体β作为预后标志物的验证，以及探讨其作为结直肠癌治疗靶点的作用。
PURPOSE: The study was designed to investigate the clinicopathological correlations, relationship to apoptotic index, and prognostic significance of estrogen receptor beta expression in colorectal carcinoma.METHODS: The study was carried out on 40 patients with newly diagnosed colorectal cancer. The patients' data were collected prospectively and the 2 years overall survival was the endpoint. Estrogen receptor beta expression was assessed by immunohistochemistry. Apoptotic body index was calculated by counting apoptotic cells using the modified TUNEL assay.RESULTS: Estrogen receptor beta positivity was detected in 65% of colorectal cancer cases, while estrogen receptor alpha positivity was found in only 7% of cases. The rate of estrogen receptor beta immunoreactivity was significantly higher in low-grade colorectal tumors. The median apoptotic index in estrogen receptor beta positive cases was significantly higher than in estrogen receptor beta negative cases (6% versus 3%; p=0.01). The median overall survival was higher in estrogen receptor beta positive cases (22 versus 18 months); however, the difference was not statistically significant.CONCLUSIONS: The study results reinforce the importance of the estrogen receptor beta rather than the estrogen receptor alpha in colorectal cancer. Lack of estrogen receptor beta expression is associated with loss of differentiation and decreased apoptosis. Future studies should include validation of estrogen receptor beta as a prognostic marker and exploration of its role as a target in the management of colorectal cancer.