Analysis and elimination of artifacts in indirect covariance NMR spectra via unsymmetrical processing
Analysis and elimination of artifacts in indirect covariance NMR spectra via unsymmetrical processing
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DOI：
10.1002/mrc.1674
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发表时间：
2005-12-01
影响因子：
2
通讯作者：
Martin, GE
中科院分区：
文献类型：
--
作者：
Blinov, KA;Larin, NI;Martin, GE
间接协方差核磁共振提供了一种通过将间接检测异核位移相关数据矩阵转换为同核数据矩阵来提取自旋-自旋连通性信息的替代方法。使用 IDR（反向直接响应）-HSQC-TOCSY 谱作为间接协方差处理的起点，获得了可描述为碳-碳 COSY 实验的谱。这些数据类似于自相关的 C-13-C-13 双量子 INADEQUATE 实验，不同之处在于间接协方差 NMR 谱仅在连续的质子化碳之间建立碳-碳连接。环戊呋喃酮和复杂的多核杂芳族萘并[2',1':5,6]-萘并[2',1':4,5]噻吩并[2,3-c]喹啉用作模型化合物。前者是一个简单的例子，因为它具有良好解析的质子谱，而后者在其拥挤的质子谱中具有相当大的共振重叠，会产生两种类型的伪影响应，在使用间接协方差核磁共振方法时必须考虑这些响应。版权所有 (c) 2005 John Wiley & Sons, Ltd.
indirect covariance NMR offers an alternative method of extracting spin-spin connectivity information via the conversion of an indirect-detection heteronuclear shift-correlation data matrix to a homonuclear data matrix. Using an IDR (inverted direct response)-HSQC-TOCSY spectrum as a starting point for the indirect covariance processing, a spectrum that can be described as a carbon-carbon COSY experiment is obtained. These data are analogous to the autocorrelated C-13-C-13 double quantum INADEQUATE experiment except that the indirect covariance NMR spectrum establishes carbon-carbon connectivities only between contiguous protonated carbons. Cyclopentafuranone and the complex polynuclear heteroaromatic naphtho[2',1':5,6]-naphtho[2',1':4,5]thieno[2,3-c]quinoline are used as model compounds. The former is a straightforward example because of its well-resolved proton spectrum, while the latter, which has considerable resonance overlap in its congested proton spectrum, gives rise to two types of artifact responses that must be considered when using the indirect covariance NMR method. Copyright (c) 2005 John Wiley & Sons, Ltd.