Perspectives in imaging using mass spectrometry
Perspectives in imaging using mass spectrometry
复制标题
DOI：
10.1039/c0cc03518a
复制
发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Cooks, R. Graham
中科院分区：
文献类型：
--
作者：
Dill, Allison L.;Eberlin, Livia S.;Cooks, R. Graham
成像质谱 (MS) 可以进行一系列显着的测量，包括根据组织化学成分（尤其是脂质和蛋白质）的详细信息诊断组织的疾病状态。最近出现的环境电离允许在开放环境中成像而无需样品制备。在这篇综述中，我们简要描述了成像质谱的历史，重点介绍了其主要技术和应用。我们还展示了通过成像 MS 获得的详细分子信息如何使该技术适用于一系列法医和临床应用，并有可能成功开发到外科手术实践。
Imaging mass spectrometry (MS) allows a remarkable range of measurements including diagnosis of disease state of tissue based on detailed information on its chemical constituents, especially lipids and proteins. The recent emergence of ambient ionization allows imaging in the open environment without sample preparation. In this review, we briefly describe the history of imaging MS highlighting its main techniques and applications. We also demonstrate how the detailed molecular information obtained by imaging MS makes this technique suitable for a range of forensic and clinical applications with the potential to be successfully developed all the way to intra-surgical practice.