PRIMATE FRONTAL EYE FIELDS .2. PHYSIOLOGICAL AND ANATOMICAL CORRELATES OF ELECTRICALLY EVOKED EYE-MOVEMENTS
PRIMATE FRONTAL EYE FIELDS .2. PHYSIOLOGICAL AND ANATOMICAL CORRELATES OF ELECTRICALLY EVOKED EYE-MOVEMENTS
复制标题
DOI：
10.1152/jn.1985.54.3.714
复制
发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
STANTON, GB
中科院分区：
文献类型：
--
作者：
BRUCE, CJ;GOLDBERG, ME;STANTON, GB
1.我们研究了清醒猕猴的额叶眼野中的单个神经元，并将它们的活动与微刺激这些神经元部位引起的扫视眼球运动进行了比较。2.扫视可以从具有小至10 μ A的电流的额眼区域的皮质灰质中的电刺激中引起。低阈值引发扫视被发现在网站的细胞与preaccadic活动。被分类为视觉运动或运动的晕厥前神经元与低（< 50 μ A）阈值最相关。3.高阈值（> 100 μ A）或没有引起的扫视与其他类别的额叶眼区神经元相关，包括仅在扫视后响应的神经元和被分类为纯视觉的扫视前神经元。4.在整个额眼领域，最佳的扫视引起preaccadic神经活动在一个给定的记录网站预测的方向和幅度的扫视，引起微刺激在该网站。与此相反，扫视后细胞的运动场通常不同于由刺激这些细胞的部位引起的扫视。5.我们将低阈值额眼场定义为产生具有刺激电流的扫视的皮层。50 μ A。它沿着弓状沟的后部，并且大部分包含在该沟的前堤中。它小于Brodmann区8，但与Walker细胞结构区8A和45的结合相对应。6.眼跳幅度的地形组织在整个额眼领域。引起的扫视的幅度范围为< 1.degree. to >30 °。腹外侧部分诱发较小的扫视，背内侧部分诱发较大的扫视。在弓状沟内，诱发性扫视通常在唇部附近较大，在眼底附近较小。7.扫视方向没有全球性的组织在整个额眼领域，然而，扫视方向改变系统的进展与微电极的小进步，和所有对侧扫视方向往往是在一个单一的电极穿透弓形沟的银行。此外，这些进展的变化方向周期性地逆转，允许特定的扫视方向在附近的皮层区域被多次表示。8.这些实验支持的假设，额叶眼场preaccadic神经元有一个因果关系的作用，在自愿扫视的产生和微刺激在额叶眼场eltered眼运动，人工激活这些细胞，因此，他们的皮层下的目标。
1. We studied single neurons in the frontal eye fields of awake macaque monkeys and compared their activity with the saccadic eye movements elicited by microstimulation at the sites of these neurons. 2. Saccades could be elicited from electrical stimulation in the cortical gray matter of the frontal eye fields with currents as small as 10 .mu.A. Low thresholds for eliciting saccades were found at the sites of cells with presaccadic activity. Presaccadic neurons classified as visuomovement or movement were most associated with low (< 50 .mu.A) thresholds. 3. High thresholds (> 100 .mu.A) or no elicited saccades were associated with other classes of frontal eye field neurons, including neurons responding only after saccades and presaccadic neurons, classified as purely visual. 4. Throughout the frontal eye fields, the optimal saccade for eliciting presaccadic neural activity at a given recording site predicted both the direction and amplitude of the saccades that were evoked by microstimulation at that site. In contrast, the movement fields of postsaccadic cells were usually different from the saccades evoked by stimulation at the sites of such cells. 5. We defined the low-threshold frontal eye fields as cortex yielding saccades with stimulation currents .ltoreq. 50 .mu.A. It lies along the posterior portion of the arcuate sulcus and is largely contained in the anterior bank of that sulcus. It is smaller than Brodmann''s area 8 but corresponds with the union of Walker''s cytoarchitectonic areas 8A and 45. 6. Saccade amplitude was topographically organized across the frontal eye fields. Amplitudes of elicited saccades ranged from < 1.degree. to > 30.degree.. Smaller saccades were evoked from the ventrolateral portion, and larger saccades were evoked from the dorsomedial portion. Within the arculate sulcus, evoked saccades were usually larger near the lip and smaller near the fundus. 7. Saccade direction had no global organization across the frontal eye fields; however, saccade direction changed in systematic progressions with small advances of the microelectrode, and all contralateral saccadic directions were often represented in a single electrode penetration down the bank of the arcuate sulcus. Furthermore, the direction of change in these progressions periodically reversed, allowing particular saccade directions to be multiply represented in nearby regions of cortex. 8. These experiments support the hypotheses that frontal eye field presaccadic neurons have a causal role in the generation of voluntary saccades and that microstimulation in the frontal eye fields elicits eye movements by artificially activating these cells, and hence their subcortical targets.