Stage-dependent fate determination of neural precursor cells in mouse forebrain
Stage-dependent fate determination of neural precursor cells in mouse forebrain
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DOI：
10.1016/j.neures.2005.01.004
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发表时间：
2005-04-01
影响因子：
2.9
通讯作者：
Gotoh, Y
中科院分区：
文献类型：
--
作者：
Hirabayashi, Y;Gotoh, Y
皮质神经前体细胞（NPC）在发育过程中依次经历扩增、神经发生和胶质发生阶段，但其内在机制尚不清楚。最近的研究已经确定了一些外在因素，调节的命运的NPC。例如，我们已经表明，Wnt信号转导诱导神经元分化的NPC在一个有益的方式。重要的是，Wnt信号传导在NPC的晚期（神经源性阶段）这样做，而不是在NPC的早期（扩增阶段）。相反，Wnt信号促进早期NPC的增殖。同样，STAT3激活配体诱导星形胶质细胞分化晚期（神经胶质阶段），但不是在早期（扩张和神经发生阶段）的NPC。NPC的这些阶段依赖性反应可能在决定每种分化细胞类型的分化时间和最终群体的大小方面发挥核心作用。(c)2005年Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
Cortical neural precursor cells (NPCs) sequentially undergo expansion, neurogenic and gliogenic phases during development, although the underlying mechanisms are poorly understood. Recent studies have identified a number of extrinsic factors that regulate the fate of NPCs. For example, we have shown that Wnt signaling induces neuronal differentiation of NPCs in an instructive manner. Importantly, Wnt signaling does so in late stage (neurogenic phase) of NPCs but not in early stage (expansion phase) of NPCs. Instead, Wnt signaling promotes proliferation of early NPCs. Likewise, STAT3-activating ligands induce astrocytic differentiation in late (gliogenic phase) but not in early (expansion and neurogenic phases) NPCs. These stage-dependent responses of NPCs might play a central role in determining the timing of differentiation and the size of final population of each differentiated cell type. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.