Beneficial effect of renal transplantation on cognitive brain function
Beneficial effect of renal transplantation on cognitive brain function
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DOI：
10.1038/ki.1996.115
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发表时间：
1996-03-01
影响因子：
19.6
通讯作者：
Grimm, G
中科院分区：
文献类型：
--
作者：
Kramer, L;Madl, C;Grimm, G
认知脑功能障碍是终末期肾病的常见并发症。为了研究肾移植的脑效应，我们研究了 15 名慢性血液透析患者和 45 名匹配的健康受试者的 P300 事件相关电位（认知脑功能的客观标志物）追踪测试和迷你精神状态。移植前，与健康受试者相比，患者的 P300 潜伏期延长（364 vs. 337 ms，P < 0.01），波幅较小（15.2 vs. 19.1 mu V），并且在试探测试和迷你精神状态中得分较低（P < 0.05）。肾移植后（14个月），P300潜伏期降低（337 ms，P < 0.01，与之前相比），波幅增加（17.4 mu V，P < 0.05，与之前相比），表明认知脑功能得到改善。越野测试和迷你心理石板有改善的趋势。移植后，P300结果、追踪测试和迷你精神状态与健康受试者没有差异。对 15 名血液透析患者中的 6 名进行促红细胞生成素治疗后的其他研究显示，P300 潜伏期缩短（改善）（351 毫秒 vs 之前的 379 毫秒，P < 0.05），移植后进一步降低（341 毫秒，P = 0.06）。我们的研究结果表明，血液透析患者的认知脑功能障碍可能通过成功的肾移植而完全逆转。
Cognitive brain dysfunction is a common complication of end-stage renal disease. To investigate the cerebral effect of renal transplantation, we studied P300 event-related potentials-an objective marker of cognitive brain function-trailmaking test and Mini-mental state in 15 chronic hemodialysis patients and 45 matched healthy subjects. Before transplantation, patients showed prolonged P300 latency (364 vs. 337 ms, P < 0.01), smaller amplitude (15.2 vs. 19.1 mu V) and scored lower (P < 0.05) in trailmaking test and Mini-mental state as compared to healthy subjects. Following renal transplantation (14 months), P300 latency decreased (337 ms, P < 0.01 vs. before) and amplitude increased (17.4 mu V, P < 0.05 vs. before), indicating improved cognitive brain function. The trailmaking test and Mini-mental slate tended to improve. Following transplantation, P300 findings, trailmaking test and Mini-mental state were not different from healthy subjects. Additional studies following erythropoietin treatment in 6 of the 15 hemodialysis patients revealed decreased (improved) P300 latency (351 vs. 379 ms before, P < 0.05) with further decrease following transplantation (341 ms, P = 0.06). Our findings indicate that cognitive brain dysfunction in hemodialysis patients may be fully reversed by successful renal transplantion.