EPIDEMIOLOGY OF HEAD TRAUMA AND NEUROCOGNITIVE IMPAIRMENT IN A MULTIETHNIC POPULATION
EPIDEMIOLOGY OF HEAD TRAUMA AND NEUROCOGNITIVE IMPAIRMENT IN A MULTIETHNIC POPULATION
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DOI：
10.1159/000110778
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发表时间：
1990-09-01
影响因子：
5.7
通讯作者：
GOLBECK, AL
中科院分区：
文献类型：
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作者：
MOLGAARD, CA;STANFORD, EP;GOLBECK, AL
这项研究检验了两个假设。这些是：(1)在未被干预的老年人中，可能是阿尔茨海默型早发性痴呆症特征的轻度认知障碍因种族而异，(2)头部创伤是与这种疾病的发展相关的危险因素。这项研究的样本包括1985年至1987年加州圣地亚哥的2105名年龄在45岁及以上的黑人、墨西哥裔美国人和白人受试者。智力功能采用Pfeiffer的便携式心理状态问卷进行测评。在Pfeiffer对教育和种族进行调整后，考试不及格率白人最高(5.7%，CI=4.26，7.57)，黑人最低(1.3%，CI=0.61，2.63)，墨西哥裔美国人居中(3.5%，CI=2.28，5.29)。黑人和白人之间的差异在0.05水平上具有统计学意义。在所有民族中，女性的失败率(4.2%CI=3.15，5.56)高于男性(3.1%，CI=2.13，4.47)，但经Pfeiffer的教育和种族调整后，差异无统计学意义。在病例对照分析中，采用Logistic回归分析对阿尔茨海默型痴呆的自我报告的头部创伤和其他可能的危险因素进行了检验。有统计学意义的关联(OR=8.577，CI=3.056，24.064)与那些在多元环境中报告头部创伤的轻度智力障碍者有关。
This study tested two hypotheses. These were: (1) that mild cognitive impairment of the type that may characterize early-onset dementia of the Alzheimer type varies by ethnic group among the noninstutionalized elderly, and (2) that head trauma is a risk factor associated with the development of this disease. This study sample consisted of a cohort of 2,105 Black, Mexican-American and White subjects aged 45 years and over at baseline in 1985-1987 in San Diego, Calif. Intellectual functioning was measured by Pfeiffer's Short Portable Mental Status Questionnaire. Percent prevalence of test failure after Pfeiffer's adjustment for education and ethnicity was highest for Whites (5.7 %, CI = 4.26, 7.57) and lowest for Blacks (1.3%, CI = 0.61, 2.63), with Mexican-Americans intermediate (3.5%, CI = 2.28, 5.29). The difference between Blacks and Whites was statistically significant at the 0.05 level. Females failed more often (4.2% CI = 3.15, 5.56) than males (3.1%, CI = 2.13, 4.47) across all ethnic groups, but the difference was not statistically significant after Pfeiffer's adjustment for education and ethnicity. Self-reported head traumas and other possible risk factors for dementia of the Alzheimer type were examined by logistic regression in a case-control analysis. A statistically significant association (OR = 8.577, CI = 3.056, 24.064) was noted for those with mild intellectual impairment who reported head traumas in a multivariate environment.