Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System.
Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System.
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内源性二氧化硫：心血管系统气体递质家族的新成员
DOI：
10.1155/2016/8961951
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发表时间：
2016
影响因子：
--
通讯作者：
Jin H
中科院分区：
文献类型：
--
作者：
Huang Y;Tang C;Du J;Jin H
二氧化硫（SO2）以前被认为是大气污染物中的有毒气体。但已发现它是哺乳动物体内含硫氨基酸通过天冬氨酸转氨酶（AAT）的转氨作用代谢而内源产生的。 SO2可以在其合酶AAT的催化下在心血管组织中产生。近年来研究表明，SO2对心血管系统具有舒张血管、调节心功能等生理作用。此外，还确定了SO2 的病理生理作用。例如，SO2 可改善全身性高血压和肺动脉高压，防止动脉粥样硬化的发展，并防止心肌缺血再灌注 (I/R) 损伤和异丙肾上腺素引起的心肌损伤。这些发现表明内源性SO2是心血管系统中一种新型气体递质，为心血管疾病提供了新的治疗靶点。
Sulfur dioxide (SO2) was previously regarded as a toxic gas in atmospheric pollutants. But it has been found to be endogenously generated from metabolism of sulfur-containing amino acids in mammals through transamination by aspartate aminotransferase (AAT). SO2 could be produced in cardiovascular tissues catalyzed by its synthase AAT. In recent years, studies revealed that SO2 had physiological effects on the cardiovascular system, including vasorelaxation and cardiac function regulation. In addition, the pathophysiological effects of SO2 were also determined. For example, SO2 ameliorated systemic hypertension and pulmonary hypertension, prevented the development of atherosclerosis, and protected against myocardial ischemia-reperfusion (I/R) injury and isoproterenol-induced myocardial injury. These findings suggested that endogenous SO2 was a novel gasotransmitter in the cardiovascular system and provided a new therapy target for cardiovascular diseases.