Curcumin nanodisks: formulation and characterization.
Curcumin nanodisks: formulation and characterization.
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DOI：
10.1016/j.nano.2010.08.002
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发表时间：
2011-04
影响因子：
5.4
通讯作者：
Ryan, Robert O.
中科院分区：
文献类型：
--
作者：
Ghosh, Mistuni;Singh, Amareshwar T. K.;Xu, Wenwei;Sulchek, Todd;Gordon, Leo I.;Ryan, Robert O.
Nanodisks (ND) are nanoscale, disk-shaped phospholipid bilayers whose edge is stabilized by apolipoproteins. In the present study, ND were formulated with the bioactive polyphenol, curcumin, at a 6:1 phospholipid:curcumin molar ratio. Atomic force microscopy revealed that curcumin-ND are particles with diameters <50 nm and thickness of a phospholipid bilayer. When formulated in ND, curcumin is water-soluble and gives rise to a characteristic absorbance spectrum with a peak centered at 420 nm. Fluorescence spectroscopy of curcumin-ND provided evidence of self-quenching. Incubation of curcumin-ND with empty-ND relieved the self-quenching, indicating redistribution of curcumin between curcumin loaded- and empty-ND. In HepG2 cells, curcumin-ND mediated enhanced cell growth inhibition compared to free curcumin. In a cell culture model of mantle cell lymphoma, curcumin-ND were a more potent inducer of apoptosis than free curcumin. The nanoscale size of the complexes, combined with their ability to solubilize curcumin, indicates ND may have in vivo therapeutic applications.
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影响因子：
4.9
作者：
Nelson, KG;Bishop, JV;Titus, R
通讯作者：
Titus, R
DOI：
10.1046/j.1432-1327.2001.02282.x
发表时间：
2001-07-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Weers, PMM;Narayanaswami, V;Ryan, RO
通讯作者：
Ryan, RO
影响因子：
10.2
作者：
Bisht S;Feldmann G;Soni S;Ravi R;Karikar C;Maitra A;Maitra A
通讯作者：
Maitra A
影响因子：
3
作者：
Marczylo, Timothy H.;Verschoyle, Richard D.;Gescher, Andreas J.
通讯作者：
Gescher, Andreas J.
影响因子：
3.3
作者：
CHIGNELL, CF;BILSKI, P;DAHL, TA
通讯作者：
DAHL, TA