Transcortical direct current potential shift reflects immediate signaling of systemic insulin to the human brain
Transcortical direct current potential shift reflects immediate signaling of systemic insulin to the human brain
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DOI：
10.2337/diabetes.53.9.2202
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发表时间：
2004-09-01
期刊：
影响因子：
7.7
通讯作者：
Born, J
中科院分区：
文献类型：
--
作者：
Hallschmid, M;Schultes, B;Born, J
循环中的胰岛素被认为是下丘脑调节能量稳态和食物摄入的主要反馈信号，尽管这种信号传导似乎被耗时的血液-脑转运所减慢。在这里，我们显示，通过记录直流电位，循环胰岛素对人脑活动的影响的快速发作。从静脉注射胰岛素（0.1 mU/kg体重作为推注）和安慰剂的27名男性中获得记录。在血糖正常条件下，低血糖得到预防，而在低血糖条件下，血浆葡萄糖达到注射后最低点43 mg/dl。所有受试者注射胰岛素后7 min内开始出现明显的负直流（DC）电位漂移。在血糖正常的情况下，胰岛素注射后10-60分钟的DC电位平均为-621.3 μ V（与注射前基线相比）。低电压将该电位降低至平均-331.2 μ V。虽然胰岛素本身并不影响振荡脑电图活动，低血糖峰值胰岛素注射后25分钟，伴随着立即增加0活动。反映脑组织中总离子变化的DC电位偏移的快速出现表明全身性胰岛素可以作为控制下丘脑和高级脑功能的即时反馈信号。
Circulating insulin is thought to provide a major feedback signal for the hypothalamic regulation of energy homeostasis and food intake, although this signaling appears to be slowed by a time-consuming blood-to-brain transport. Here we show, by recording direct current potentials, a rapid onset of the effects of circulating insulin on human brain activity. Recordings were obtained from 27 men who were intravenously injected with insulin (0.1 mU/kg body wt as bolus) and placebo. In a euglycemic condition, hypoglycemia was prevented, while in the hypoglycemic condition, plasma glucose reached a postinjection nadir of 43 mg/dl. Insulin injection induced a marked negative direct current (DC) potential shift starting within 7 min in all subjects. With euglycemic conditions, the DC potential at 10-60 min postinsulin injection averaged -621.3 muV (compared with preinjection baseline). Hypoglycemia reduced this potential to an average of -331.2 muV. While insulin per se did not affect oscillatory electroencephalographic activity, hypoglycemia peaking 25 min after insulin injection was accompanied by an immediate increase in 0 activity. The rapid emergence of the DC potential shift, reflecting gross ionic changes in brain tissues, indicates that systemic insulin can serve as an immediate feedback signal in the control of hypothalamic and higher brain functions.