Isatisine a, a novel alkaloid with an unprecedented skeleton from leaves of isatis indigotica
Isatisine a, a novel alkaloid with an unprecedented skeleton from leaves of isatis indigotica
复制标题
DOI：
10.1021/ol701540y
复制
发表时间：
2007-10-11
期刊：
影响因子：
5.2
通讯作者：
Ma, Yun-Bao
中科院分区：
文献类型：
--
作者：
Liu, Ji-Feng;Jiang, Zhi-Yong;Ma, Yun-Bao
从板蓝根（Isatis indigotica Fort.）中分离得到9 α，13 α-二羟基异亚丙基靛素A（1），它是从靛素A（2）衍生而来的，具有前所未有的稠合五环骨架。通过核磁共振分析和单晶X射线衍射分析确定了化合物的结构和相对构型。化合物1显示出中等的抗HIV-1活性，EC 50 = 37.8 μ M，S1 = 7.98。
9 alpha,13 alpha-Dihydroxylisopropylidenylisatisine A (1), which was derived from isatisine A (2) and possessed an unprecedented fused pentacyclic skeleton, was isolated from the leaves of Isatis indigotica Fort. The structure and relative configuration were elucidated on the basis of extensive NMR analyses and finally determined by single-crystal X-ray diffraction. Compound 1 showed moderate anti-HIV-1 activity with EC50 = 37.8 mu M and S1 = 7.98.