Flexible and Biocompatible Physical Unclonable Function Anti-Counterfeiting Label
Flexible and Biocompatible Physical Unclonable Function Anti-Counterfeiting Label
复制标题
灵活且生物相容的物理不可克隆功能防伪标签
DOI：
10.1002/adfm.202102108
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发表时间：
2021-06-18
影响因子：
19
通讯作者：
Shan, Chong-Xin
中科院分区：
文献类型：
--
作者：
Hu, Yan-Wei;Zhang, Tai-Ping;Shan, Chong-Xin
光学物理不可克隆函数（PUF）已被证明是最有效的防伪策略之一。然而，还没有开发出具有柔性和生物相容性的光学PUF，限制了其应用场景。在此，生物相容性和灵活的光学PUF标签的开发随机嵌入微金刚石在丝素蛋白膜。PUF标签可以保形地贴在复杂形状物体的表面上，提供所需的保护，防止假冒产品和内部产品。在这个系统中，丝素蛋白膜作为一个灵活的和生物相容的基板，而拉曼信号的微金刚石作为响应的激发。微金刚石极高的稳定性和随机分布保证了PUF的性能，最终实现了2（10000）的最大编码能力。细胞毒性分析结果也验证了PUF系统的生物安全性。此外，制备的PUF标签附着在聚乙烯材料表面，人体皮肤，甚至已经植入鸡皮肤组织下，有望其实际应用。
Optical physical unclonable functions (PUFs) have been proven to be one of the most effective anti-counterfeiting strategies. However, optical PUFs endowed with flexibility and biocompatibility have not been developed, limiting their application scenarios. Herein, biocompatible and flexible optical PUF labels are developed by randomly embedding microdiamonds in silk fibroin films. The PUF labels can be conformally attached onto the surface of complex shaped objects, providing the desired protection against fake and interior products. In this system, silk fibroin films serve as a flexible and biocompatible substrate, while the Raman signal of the microdiamonds serves as response of the excitation. The extremely high stability and random distribution of the microdiamonds ensure the performance of PUFs, and the maximum encoding capability of 2(10000) is finally realized. The cytotoxicity analysis results also verify the biosafety of the PUF system. In addition, the as-prepared PUF labels are attached onto the surface of polyethylene material, and human skin, and even have been implanted under chicken skin tissue, promising their practical applications.