INFLUENCE OF HOUSING CONDITIONS ON THE ACQUISITION OF INTRAVENOUS HEROIN AND COCAINE SELF-ADMINISTRATION IN RATS
INFLUENCE OF HOUSING CONDITIONS ON THE ACQUISITION OF INTRAVENOUS HEROIN AND COCAINE SELF-ADMINISTRATION IN RATS
复制标题
DOI：
10.1016/0091-3057(89)90490-5
复制
发表时间：
1989-08-01
影响因子：
3.6
通讯作者：
WISE, RA
中科院分区：
文献类型：
--
作者：
BOZARTH, MA;MURRAY, A;WISE, RA
分组饲养和单独饲养的大鼠接受了静脉注射海洛因或可卡因强化的杠杆按压反应的测试；在每种饲养条件下的动物很快学会了自我给药。在第一个实验中，隔离的大鼠比集体饲养的动物更早学会自我注射海洛因，但在测试的第五周，两组大鼠自我注射的海洛因水平相似。在第二个实验中，两组人以相同的速度学会了可卡因的自我给药，并且在整个实验过程中，两组人都自我给予了类似水平的可卡因。这些数据表明，虽然社会隔离可以影响海洛因自我给药的水平，但隔离并不是海洛因或可卡因注射得到加强的必要条件。
Group-housed and individually housed rats were tested for the acquisition of a lever-pressing response reinforced by intravenous heroin or cocaine; animals in each housing condition quickly learned to self-administer drug. In the first experiment the isolated rats learned to self-administer heroin earlier than the group-housed animals, but the two groups self-administered similar levels of heroin by the fifth week of testing. In the second experiment cocaine self-administration was learned with equal speed in the two groups, and similar levels of cocaine were self-administered by both groups throughout the experiment. These data indicate that while social isolation can influence levels of heroin self-administration, isolation is not a necessary condition for heroin or cocaine injections to be reinforcing.