Polymer nanogels: a versatile nanoscopic drug delivery platform.
Polymer nanogels: a versatile nanoscopic drug delivery platform.
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DOI：
10.1016/j.addr.2012.02.002
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发表时间：
2012-06-15
影响因子：
16.1
通讯作者：
Thayumanavan S
中科院分区：
文献类型：
--
作者：
Chacko RT;Ventura J;Zhuang J;Thayumanavan S
在这篇综述中，我们把重点放在交联聚合物纳米凝胶，一个有前途的平台，具有“理想”的药物输送载体的特点。一些关键方面的药物输送载体的设计，如稳定性，响应生物相关的刺激，被动靶向，主动靶向，毒性和易于合成进行了讨论。我们讨论了几个交付系统，在这个光和突出的一些例子的系统，满足部分或全部这些设计要求。特别是，我们指出的优点，交联聚合物系统带来的药物输送。我们回顾了纳米凝胶的合成方法，并总结了纳米凝胶在药物输送中的各种应用。
In this review we put the spotlight on crosslinked polymer nanogels, a promising platform that has the characteristics of an “ideal” drug delivery vehicle. Some of the key aspects of drug delivery vehicle design like stability, response to biologically relevant stimuli, passive targeting, active targeting, toxicity and ease of synthesis are discussed. We discuss several delivery systems in this light and highlight some examples of systems, which satisfy some or all of these design requirements. In particular, we point to the advantages that crosslinked polymeric systems bring to drug delivery. We review some of the synthetic methods of nanogel synthesis and conclude with the diverse applications in drug delivery where nanogels have been fruitfully employed.