The reduction of arterial tension produced by stevioside is dependent on nitric oxide synthase activity when the endothelium is intact.
The reduction of arterial tension produced by stevioside is dependent on nitric oxide synthase activity when the endothelium is intact.
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DOI：
10.1540/jsmr.44.1
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发表时间：
2008-02
期刊：
影响因子：
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通讯作者：
Elaine Campana Sanches Bornia;Valéria do Amaral;R. B. Bazotte;W. Alves-do-prado
中科院分区：
文献类型：
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作者：
Elaine Campana Sanches Bornia;Valéria do Amaral;R. B. Bazotte;W. Alves-do-prado
在用去甲肾上腺素或KCl预收缩的内皮完整大鼠主动脉环制剂中，NG-硝基L-精氨酸（L-NOARG，0.1 mM）和1H-[1，2，4] oxidazolo [4，3-a] quinoxalin-1-one（ODQ，10 μ M）拮抗了甜菊苷诱导的血管张力降低，但当用内皮剥脱的主动脉环进行实验时，这种拮抗作用没有发生。数据表明，当内皮未受损时，甜菊苷产生的血管舒张依赖于一氧化氮合酶和鸟苷酸环化酶活性。
In endothelium-intact rat aortic ring preparations pre-contracted with norepinephrine or KCl, NG-nitro L-arginine (L-NOARG, 0.1 mM) and 1H-[1,2,4] oxidiazolo [4,3-a] quinoxalin-1-one (ODQ, 10 microM) antagonized the reduction of the vascular tone induced by stevioside, but this antagonism did not occur when the experiment was performed with endothelium-denuded aortic rings. The data indicates that the vasodilatation produced by stevioside is dependent on nitric oxide synthase and guanylate cyclase activities when the endothelium is not damaged.