A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles.
A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles.
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DOI：
10.1002/ejoc.201601336
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发表时间：
2017-01-03
影响因子：
2.8
通讯作者：
Taylor RJK
中科院分区：
文献类型：
--
作者：
Hurst TE;Taylor RJK
据报道，通过简单的 2-[2-(芳基氨基)芳基]丙二酸酯的铜催化自由基交叉脱氢偶联合成吖啶类和相关化合物。该方法可以进一步简化为一锅法，涉及在 Pd 催化下通过丙二酸二乙酯与 2-溴二芳基胺的 α-芳基化原位形成 2-[2-(芳基氨基)芳基]丙二酸酯，然后进行 Cu 催化环化。
The synthesis of acridanes and related compounds through a Cu‐catalysed radical cross‐dehydrogenative coupling of simple 2‐[2‐(arylamino)aryl]malonates is reported. This method can be further streamlined to a one‐pot protocol involving the in situ fomation of the 2‐[2‐(arylamino)aryl]malonate by α‐arylation of diethyl malonate with 2‐bromodiarylamines under Pd catalysis, followed by Cu‐catalysed cyclisation.