Receptor inhibition by immunoglobulins: specific inhibition by autistic children, their relatives, and control subjects.
Receptor inhibition by immunoglobulins: specific inhibition by autistic children, their relatives, and control subjects.
复制标题
免疫球蛋白的受体抑制：自闭症儿童、其亲属和对照受试者的特异性抑制。
DOI：
10.1007/bf01066419
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发表时间：
1993
影响因子：
3.9
通讯作者：
Leventhal,BL
中科院分区：
文献类型：
--
作者：
CookJr,EH;Perry,BD;Dawson,G;Wainwright,MS;Leventhal,BL
对42名自闭症儿童的父母、15名自闭症儿童、17名自闭症儿童的兄弟姐妹和12名无关的正常成人对照进行了研究，以确定从他们的血浆中分离的免疫球蛋白是否会抑制5-HT 1A激动剂[3 H]-8-羟基-N，N-二丙基-2-氨基四氢萘（DPAT）与人海马膜中5-HT 1A受体的结合。父母、自闭症儿童、兄弟姐妹或无关对照组的DPAT结合抑制百分比均值之间无显著差异。此外，在自闭症儿童、他们的父母、他们的兄弟姐妹或无关的对照组中，DPAT抑制>15%的受试者比例没有差异。免疫球蛋白抑制作用对5 HT 1A受体结合位点无特异性，因为免疫球蛋白抑制与5 HT 2、D1、D2和α2-肾上腺素能结合位点的结合。从正常对照组中分离的免疫球蛋白抑制[3 H]-萝芙木碱在α2-肾上腺素能位点的结合低于自闭症儿童及其父母和兄弟姐妹的免疫球蛋白。本研究不支持5-HT 1A或5-HT 2受体自身抗体是孤独症特征的假说。
Forty-two parents of children with autistic disorder, 15 children with autistic disorder, 17 siblings of children with autistic disorder, and 12 unrelated normal adult controls were studied to determine if immunoglobulins isolated from their plasma would inhibit binding of the 5HT1Aagonist, [3H]-8-hydroxy-N,N-dipropyl-2-aminotetralin (DPAT) to 5HT1Areceptors in human hippocampal membranes. There were no significant differences among the means of percentage inhibition of DPAT binding of parents, children with autistic disorder, siblings, or unrelated controls. In addition, there were no differences in the proportion of subjects with >15% DPAT inhibition among autistic children, their parents, their siblings, or unrelated controls. Immunoglobulin inhibition was not specific for the 5HT1Areceptor binding site, since immunoglobulins inhibited binding to 5HT2, D1, D2, and α2-adrenergic binding sites. The immunoglobulins isolated from normal controls inhibited [3H]-rauwolscine binding at α2-adrenergic sites less than immunoglobulins of children with autistic disorder and their parents and siblings. This study did not support the hypothesis that autoantibodies to 5HT1Aor 5HT2receptors are characteristic of autistic disorder.