Analysis and Measurements of an Urea Biosensor Based on Instrumentation Amplifier Chip With Cross-Coupled Technique
Analysis and Measurements of an Urea Biosensor Based on Instrumentation Amplifier Chip With Cross-Coupled Technique
复制标题
基于仪表放大器芯片交叉耦合技术的尿素生物传感器的分析与测量
DOI：
--
复制
发表时间：
2023
影响因子：
5.6
通讯作者：
Chun
中科院分区：
文献类型：
--
作者：
Po;Tai;Wei;Chun
在这项工作中，我们设计了一个高共模抑制比（CMRR）和低单位增益频率（UGF）交叉耦合仪表放大器（CCIA）。本设计由台湾积体电路制造公司（TSMC）0.18- $mu ext{m}$ CMOS工艺技术。利用这三种交叉耦合运算放大器，分别在+1.8 V和−1.8 V电源电压下设计了CCIA，仪表放大器（IA）的电压增益为56.92 dB，共模抑制比（CMRR）为126.08 dB。该IA被应用于阵列式RuO 2尿素生物传感器作为读出电路。并对尿素生物传感器的传感特性进行了分析。实验结果表明，该传感器的平均灵敏度为2.933 mV/（mg/dL），线性度为0.998。利用所提出的IA，由于简单、方便和低成本，可以实现有效的测量系统。
In this work, we design a high common-mode rejection ratio (CMRR) and low unity gain frequency (UGF) cross-coupled instrumentation amplifier (CCIA). This design was implemented by the Taiwan Semiconductor Manufacturing Company (TSMC) 0.18- $mu ext{m}$ CMOS process technology. By using the three proposed cross-coupled operational amplifier, the CCIAs was designed with the power supply of +1.8 and −1.8 V. The instrumentation amplifier (IA) achieved a voltage gain of 56.92 dB with a CMRR of 126.08 dB. This IA was applied on an arrayed RuO2 urea biosensor as a readout circuit. Moreover, the sensing characteristics of the urea biosensor were analyzed. The experimental results show that our arrayed RuO2 urea biosensor combined with CCIA has a good average sensitivity of 2.933 mV/(mg/dL) and a linearity of 0.998. With the proposed IA, an effective measurement system can be achieved due to simplicity, convenience, and low cost.