Statistical Characterization of Human Brain Deformation During Mild Angular Acceleration Measured In Vivo by Tagged Magnetic Resonance Imaging
Statistical Characterization of Human Brain Deformation During Mild Angular Acceleration Measured In Vivo by Tagged Magnetic Resonance Imaging
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DOI：
10.1115/1.4040230
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发表时间：
2018-10-01
影响因子：
1.7
通讯作者：
Pham, Dzung L.
中科院分区：
文献类型：
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作者：
Chan, Deva D.;Knutsen, Andrew K.;Pham, Dzung L.
了解体内脑生物力学行为对研究创伤性脑损伤（TBI）机制和预防至关重要。使用标记磁共振成像，我们测量了34名健康志愿者在头部轻微角加速度下的时空大脑变形。在每个受试者的整个大脑中检测二维（2D）拉格朗日应变。应变指标在接触填充停止后不久达到峰值，对应于头部减速后大脑的惯性响应。在峰值变形时，最大剪切应变至少为3%，皮质灰质的面积分数（中位数+/-标准误差）为23.5 +/- 1.8%，白质为15.9 +/- 1.4%，深部灰质为4.0 +/- 1.5%。皮层灰质应变在与填充物初次接触的一侧颞叶皮层以及对侧颞叶、额叶和顶叶皮层更大。这些来自健康志愿者群体的组织水平变形提供了对已知运动学响应的全体积脑变形的首次体内测量。虽然不同组织类型和皮质叶的应变存在差异，但男性和女性的头部加速度和应变指标没有显著差异。这些累积结果突出了大脑机械反应的重要运动学特征，可用于促进TBI计算模拟的评估。
Understanding of in vivo brain biomechanical behavior is critical in the study of traumatic brain injury (TBI) mechanisms and prevention. Using tagged magnetic resonance imaging, we measured spatiotemporal brain deformations in 34 healthy human volunteers under mild angular accelerations of the head. Two-dimensional (2D) Lagrangian strains were examined throughout the brain in each subject. Strain metrics peaked shortly after contact with a padded stop, corresponding to the inertial response of the brain after head deceleration. Maximum shear strain of at least 3% was experienced at peak deformation by an area fraction (median +/- standard error) of 23.5 +/- 1.8% of cortical gray matter, 15.9 +/- 1.4% of white matter, and 4.0 +/- 1.5% of deep gray matter. Cortical gray matter strains were greater in the temporal cortex on the side of the initial contact with the padded stop and also in the contralateral temporal, frontal, and parietal cortex. These tissue-level deformations from a population of healthy volunteers provide the first in vivo measurements of full-volume brain deformation in response to known kinematics. Although strains differed in different tissue type and cortical lobes, no significant differences between male and female head accelerations or strain metrics were found. These cumulative results highlight important kinematic features of the brain's mechanical response and can be used to facilitate the evaluation of computational simulations of TBI.