Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys
Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys
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DOI：
10.1007/s00221-005-0129-4
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发表时间：
2006-02-01
影响因子：
2
通讯作者：
Nudo, RJ
中科院分区：
文献类型：
--
作者：
Barbay, S;Plautz, EJ;Nudo, RJ
大脑皮层内的局灶性损伤通过时间依赖性代谢和生理反应导致备用皮层内的功能重组。生理变化也与特定的损伤后行为体验有关。了解这些因素是如何相互作用的，有助于制定中风后的康复干预计划。本研究的目的是评估功能的影响，延迟康复行为的经验后，在初级运动皮层（M1）在一个既定的非人灵长类动物，缺血性梗死模型的运动表征。5只成年松鼠猴在M1实验性缺血性梗死诱导前和1个月后接受运动技能任务训练。在梗死前和梗死后1个月和2个月，使用标准电生理程序在M1内推导出手部的运动表征。这项研究的结果表明，即使恢复运动技能是类似于先前的研究，在松鼠猴早期训练后，不像早期训练，延迟训练并没有导致在维护备用的手代表性内的M1周围梗死手区。相反，延迟训练导致在自发恢复期间，持续延迟训练后，备用手的代表性大幅下降。此外，延迟训练导致同时诱发的运动，通常是独立的增加。这些结果表明，损伤后的行为经验，如运动技能训练，可能会调制梗死周围皮层可塑性在不同的方式在急性与慢性阶段中风后。
A focal injury within the cerebral cortex results in functional reorganization within the spared cortex through time-dependent metabolic and physiological reactions. Physiological changes are also associated with specific post-injury behavioral experiences. Knowing how these factors interact can be beneficial in planning rehabilitative intervention after a stroke. The purpose of this study was to assess the functional impact of delaying the rehabilitative behavioral experience upon movement representations within the primary motor cortex (M1) in an established nonhuman primate, ischemic infarct model. Five adult squirrel monkeys were trained on a motor-skill task prior to and 1 month after an experimental ischemic infarct was induced in M1. Movement representations of the hand were derived within M1 using standard electrophysiological procedures prior to the infarct and again one and two months after the infarct. The results of this study show that even though recovery of motor skills was similar to that of a previous study in squirrel monkeys after early training, unlike early training, delayed training did not result in maintenance of the spared hand representation within the M1 peri-infarct hand area. Instead, delaying training resulted in a large decrease in spared hand representation during the spontaneous recovery period that persisted following the delayed training. In addition, delayed training resulted in an increase of simultaneously evoked movements that are typically independent. These results indicate that post-injury behavioral experience, such as motor skill training, may modulate peri-infarct cortical plasticity in different ways in the acute versus chronic stages following stroke.