Age at first intoxication and alcohol use disorders in southwest California Indians
Age at first intoxication and alcohol use disorders in southwest California Indians
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DOI：
10.1111/j.1530-0277.2006.00222.x
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发表时间：
2006-11-01
影响因子：
3.2
通讯作者：
Wilhelmsen, Kirk C.
中科院分区：
文献类型：
--
作者：
Ehlers, Cindy L.;Slutske, Wendy S.;Wilhelmsen, Kirk C.
背景资料：在几项国家调查中，首次饮酒和/或经常饮酒的年龄越小，酒精依赖的发生可能性就越大。一些研究表明，第一次饮酒的年龄主要是一个环境驱动的变量，而另一些研究表明，它可能部分是由表现出问题行为的一般脆弱性介导的。虽然美洲原住民，总体而言，有最高的患病率酒精依赖的任何美国种族群体，中毒的发病年龄与酒精依赖的关系在美洲原住民population.Methods：人口统计信息和DSM-III-R的诊断，从525西南加州（SWC）印第安成年人居住在连续保留。采用生存分析、考克斯回归和Logistic回归分析探讨首次中毒年龄与酒精依赖发生的关系。首次中毒发病年龄的遗传度也确定使用SOLAR.Results：首次中毒的年龄没有发现在这个人群中是遗传的。然而，即使考虑到包括外部诊断在内的其他几个风险因素，发现早期中毒与酒精依赖发作时间缩短和患病率增加显著相关。结论：这些数据表明，在减少未成年人饮酒方面进行有效的环境预防工作可能是降低这一高风险地区酒精依赖流行率的重要战略。风险人群。
Background: In several national surveys, a younger age of onset of first drink and/or regular drinking has been associated with a higher likelihood of the development of alcohol dependence. Some studies have suggested that age at first drink is primarily an environmentally driven variable whereas others suggest that it may be partially mediated by a general vulnerability to exhibit problem behaviors. Although Native Americans, overall, have the highest prevalence of alcohol dependence of any U.S. ethnic group, the relationship of age of onset of intoxication with alcohol dependence in Native American populations is relatively unknown.Methods: Demographic information and DSM-III-R diagnoses were obtained from 525 Southwest California (SWC) Indian adults residing on contiguous reservations. Survival analyses and Cox and logistic regression were used to investigate the relationship between age of onset of first intoxication and the development of alcohol dependence. Heritability of the age of onset of first intoxication was also determined using SOLAR.Results: Age at first intoxication was not found to be heritable in this population. Early onset of intoxication, however, was found to be significantly associated with both a shorter time to onset of alcohol dependence and increased prevalence in this population, even on taking into account several other risk factors including externalizing diagnoses.Conclusions: These data suggest that effective environmental prevention efforts at reducing underage drinking may be an important strategy to lower the prevalence of alcohol dependence in this high-risk population.