Body Fat Distribution, Adipocyte Size, and Metabolic Characteristics of Nondiabetic Adults
Body Fat Distribution, Adipocyte Size, and Metabolic Characteristics of Nondiabetic Adults
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DOI：
10.1210/jc.2009-1353
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发表时间：
2010-01-01
影响因子：
5.8
通讯作者：
Jensen, Michael D.
中科院分区：
文献类型：
--
作者：
Mundi, Manpreet S.;Karpyak, Maksym V.;Jensen, Michael D.
背景：尚不清楚脂肪细胞大小或身体脂肪分布是否与肥胖的代谢并发症最密切相关。目的：我们的目的是测试脂肪细胞大小是否比身体成分更好地预测肥胖的代谢特征。设计、参与者和环境：我们分析了从 1995 年至 2008 年间参与梅奥综合临床研究中心进行的研究的 432 名主要是白人研究志愿者（264 名女性）收集的代谢和人体测量数据之间的关系。结果测量：代谢变量包括空腹血糖、胰岛素和甘油三酯浓度。人体测量变量包括身体成分、脂肪分布以及皮下腹部和股骨脂肪细胞大小。结果：使用单变量和多变量回归分析，通过内脏脂肪区域的计算机断层扫描可以最好地预测男性和女性的空腹甘油三酯。女性空腹胰岛素浓度最好通过皮下腹部脂肪面积预测（r(2) = 0.40；P < 0.01），男性通过体重指数预测（r(2) = 0.53；P < 0.0001）；脂肪细胞大小并不独立起作用。在男性中，空腹血糖浓度通过股骨脂肪细胞大小（部分 r(2) = 0.07；P = 0.002）、体重指数（部分 r(2) = 0.03；P = 0.07）和年龄（部分 r(2) = 0.02；P = 0.06）来预测。在女性中，空腹血糖是通过腹部皮下脂肪面积（部分 r(2) = 0.12；P < 0.0001）和年龄（部分 r(2) = 0.03；P = 0.01）来预测的。结论：我们的假设，即脂肪细胞大小是代谢特征的最佳预测因子，在该人群中并未得到支持。另一种解释是，脂肪量和身体脂肪分布对代谢反应的影响比脂肪细胞大小的影响更大。 (临床内分泌代谢杂志 95: 67-73, 2010)
Context: It is unclear whether adipocyte size or body fat distribution is most strongly linked to the metabolic complications of obesity.Objective: Our objective was to test whether adipocyte size better predicts metabolic characteristics of obesity than body composition.Design, Participants, and Setting: We analyzed the relationship between metabolic and anthropometric data collected from 432 largely Caucasian research volunteers (264 women) participating in studies conducted in the Mayo General Clinical Research Center between 1995 and 2008.Main Outcome Measures: Metabolic variables included fasting plasma glucose, insulin, and triglyceride concentrations. Anthropometric variables included body composition, fat distribution, and sc abdominal and femoral adipocyte size.Results: Using both univariate and multivariate regression analysis, fasting triglyceride in both men and women was best predicted by computed tomography of visceral fat area. Fasting insulin concentrations were best predicted by sc abdominal fat area in women (r(2) = 0.40; P < 0.01) and body mass index in men (r(2) = 0.53; P < 0.0001); adipocyte size did not contribute independently. In men, fasting glucose concentrations were predicted by femoral adipocyte size (partial r(2) = 0.07; P = 0.002), body mass index (partial r(2) = 0.03; P = 0.07), and age (partial r(2) = 0.02; P = 0.06). In women, fasting glucose was predicted by abdominal sc fat area (partial r(2) = 0.12; P < 0.0001) and age (partial r(2) = 0.03; P = 0.01).Conclusions: Our hypothesis that adipocyte size is the best predictor of metabolic characteristics was not supported in this population. The alternative explanation is that fat mass and body fat distribution have more influence on metabolic responses than adipocyte size. (J Clin Endocrinol Metab 95: 67-73, 2010)