Relationships of Soluble E-Selectin and High-Sensitivity C-Reactive Protein with Carotid Atherosclerosis in Japanese Men
Relationships of Soluble E-Selectin and High-Sensitivity C-Reactive Protein with Carotid Atherosclerosis in Japanese Men
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DOI：
10.5551/jat.no182
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发表时间：
2009-01-01
影响因子：
4.4
通讯作者：
Iso, Hiroyasu
中科院分区：
文献类型：
--
作者：
Sakurai, Susumu;Kitamura, Akihiko;Iso, Hiroyasu
目的：E-选择素和C-反应蛋白与颈动脉粥样硬化有关;然而，关于这种关联的研究结果并不一致。方法和结果：我们进行了一项横断面研究，以检查可溶性E-选择素（sE-选择素）和高敏C反应蛋白（hs-CRP）水平与颈动脉内膜中层厚度（IMT）的关系505名60-74岁的日本男性。校正年龄、hs-CRP和其他心血管危险因素后，颈总动脉（CCA）和颈内动脉（伊卡）的最大IMT与sE-选择素水平呈正相关：对于sE-选择素的最低至最高三分位数，最大CCA IMT的平均值分别为1.12、1.21和1.27 mm，p = 0.04，而伊卡IMT的平均值为1.73，分别为2.09和2.09 mm，p = 0.009。校正年龄、sE-选择素和其他心血管危险因素后，CCA的最大IMT往往与hs-CRP水平呈正相关：hs-CRP最低至最高三分位数的最大CCA IMT平均值分别为1.10、1.25和1.26 mm，p = 0.06。与sE-选择素和hs-CRP最低三分位数的受试者相比，最高三分位数的受试者异质性斑块的患病率较高：多变量比值比为2.2（1.0-3.7），p = 0.002和1.6（1.0-2.7），p = 0.046。结论：血清sE-selectin和hs-CRP水平可作为一般人群动脉粥样硬化的生物标志物。
Aim: E-selectin and C-reactive protein have been linked with carotid atherosclerosis; however, the findings on this association have been inconsistent.Methods and Results: We conducted a cross-sectional study to examine the associations of soluble E-selectin (sE-selectin) and high-sensitivity-CRP (hs-CRP) levels with carotid intima-media thickness (IMT) in 505 Japanese men aged 60-74 years. Maximum IMT of common (CCA) and internal carotid arteries (ICA) was positively associated with sE-selectin levels after adjustment for age, hs-CRP and other cardiovascular risk factors: means of maximum CCA IMT were 1.12, 1.21 and 1.27 mm for the lowest to highest tertiles of sE-selectin, respectively, p = 0.04, and those of ICA IMT were 1.73, 2.09 and 2.09 mm, respectively, p = 0.009. Maximum IMT of CCA tended to be positively associated hs-CRP levels after adjustment for age, sE-selectin and other cardiovascular risk factors: means of maximum CCA IMT were 1.10, 1.25, and 1.26 mm, for the lowest to highest tertiles of hs-CRP, respectively, p = 0.06. Compared with subjects with the lowest tertiles of sE-selectin and hs-CRP, those with the highest tertiles had a higher prevalence of heterogeneous plaque: multivariable odds ratios were 2.2 (1.0-3.7), p = 0.002 and 1.6 (1.0-2.7), p = 0.046, respectively.Conclusions: Serum levels of sE-selectin and hs-CRP could be biomarkers for atherosclerosis in general populations.