L-arginine and antineutrophil serum enable venular control of capillary perfusion in hypercholesterolemic rats.
L-arginine and antineutrophil serum enable venular control of capillary perfusion in hypercholesterolemic rats.
复制标题
L-精氨酸和抗中性粒细胞血清能够控制高胆固醇血症大鼠的毛细血管灌注。
DOI：
10.1038/sj.mn.7800162
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Harris,NormanR
中科院分区：
文献类型：
--
作者：
Nellore,Kavitha;Harris,NormanR
ObjectiveThe purpose of this study was to investigate and counteract dysfunctional control of capillary flow in hypercholesterolemia. Capillary flow is controlled by arteriolar tone, which in turn is influenced by mediators released from closely paired venules in a mechanism that involves nitric oxide (NO). However, venular control of capillary flow is altered with hypercholesterolemia.MethodsRats were given a normal or high-cholesterol diet before measurements of mesenteric capillary red blood cell velocity. The arteriolar pathway leading to the capillary was videotaped to measure the percent of the surrounding area (within 15 µm) that was occupied by a venule (% pairing).ResultsVenule-paired arterioles were significantly smaller in hypercholesterolemia compared with normocholesterolemia, corresponding to slower capillary flow. A positive correlation between capillary velocity and % pairing observed in normocholesterolemia was not observed during NO synthase inhibition or in hypercholesterolemic rats. However, positive correlations between the two parameters were found in hypercholesterolemia when the rats were given drinking water supplementation of L-arginine or an injection of antineutrophil serum, both of which tended to improve velocity in capillaries branching from venulepaired arteriolar pathways.ConclusionsDysfunctional `venular control of capillary perfusion in hypercholesterolemia may be a consequence of a neutrophil-mediated deficiency of NO.Microcirculation(2002)9,477–485. doi:10.1038/sj.mn.7800162.
