Pharmacology, Toxicology, Clinical Efficacy, and Adverse Effects of Calcium Polycarbophil, An Enteral Hydrosorptive Agent
Pharmacology, Toxicology, Clinical Efficacy, and Adverse Effects of Calcium Polycarbophil, An Enteral Hydrosorptive Agent
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肠内吸水剂聚卡波非钙的药理学、毒理学、临床疗效和不良反应
DOI：
10.1002/j.1875-9114.1982.tb03168.x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
I. Danhof
中科院分区：
文献类型：
--
作者：
I. Danhof
聚碳酸钙是聚丙烯酸与二乙二醇交联制得的钙盐。它在化学和生理上都是惰性的。在稀碱中，它具有显著的亲水性(是其重量的60-100倍)，这是其治疗用途的基础。成人每天服用4-5克，似乎相当安全，无毒，不干扰消化或吸收，也不会引起胃肠道刺激。它似乎在治疗便秘和由于功能性或器质性原因引起的腹泻方面都有效。连续使用几天，效果才会显现。临床研究相对较少，范围从几乎是轶事性质的不受控制的、非盲目的评估，到控制良好的双盲交叉研究。其他关于饮食影响、锻炼和患者依从性的仔细对照研究将是有帮助的。副作用很小，包括上腹胀或沉重、腹胀、腹胀和腹胀。与所有成块剂一样，有胃肠道狭窄病变的人不应使用聚碳酸钙。
Calcium polycarbophil is the calcium salt of polyacrylic acid crosslinked with divinyl glycol. It is chemically and physiologically inert. In dilute alkali it possesses marked hydrophilic capacity (60 to 100 times its weight), which is the basis for its therapeutic use. In daily dosages of 4 to 5 g in adults, it appears to be quite safe, is non‐toxic, does not interfere with digestion or absorption, and does not cause gastrointestinal irritation. It appears to be effective in the treatment of both constipation and diarrhea due to functional or organic causes. Several days of continuous use are necessary before effectiveness becomes apparent. Clinical studies, of which there are relatively few, range from uncontrolled, unblinded evaluations of an almost anecdotal nature to well controlled, double‐blind, crossover studies. Additional carefully controlled studies on dietary influences, exercise, and patient compliance would be helpful. Adverse effects, which are minimal, include epigastric fullness or heaviness, abdominal distention and bloating, and flatulence. As with all bulk‐forming agents, calcium polycarbophil should not be used by persons who have stenotic lesions of the gastrointestinal tract.