Chemotherapy-induced prospective memory impairment in breast cancer patients with different hormone receptor expression.
Chemotherapy-induced prospective memory impairment in breast cancer patients with different hormone receptor expression.
复制标题
不同激素受体表达的乳腺癌患者化疗引起的前瞻性记忆障碍
DOI：
10.1097/md.0000000000006514
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发表时间：
2017-03
期刊：
影响因子：
1.6
通讯作者：
Cheng H
中科院分区：
文献类型：
--
作者：
Li W;Gan C;Lv Y;Wang S;Cheng H
摘要本研究旨在探讨雌激素受体（ER）和孕激素受体（PR）表达不同的乳腺癌患者的前瞻性记忆障碍。将120例术后化疗的乳腺癌患者分为两组。A组包括60例ER - /PR -状态患者，B组包括60例ER+/PR+状态患者。术后6个周期的辅助化疗后，所有患者均进行神经心理和前瞻记忆测试，如Mini-Mental State Examination （MMSE）、verbal流畅性测试（VFT）、digital span test (DST)，以及event-based prospective memory （EBPM）和time-based prospective memory （TBPM）测试。神经心理学背景测试结果显示，ER - /PR -组和ER+/PR+组乳腺癌患者的MMSE、DST和TBPM评分差异无统计学意义（*:P > 0.05），而ER+/PR+状态的乳腺癌患者的VFT和EBPM评分显著高于ER - /PR -状态的乳腺癌患者（**:P < 0.01），表明ER - /PR -状态的乳腺癌患者EBPM有显著损害，但TBPM无显著损害。本研究结果提示乳腺癌患者激素受体的不同表达可能与化疗诱导的前瞻性记忆障碍的异质性有关。
Abstract This study aimed to investigate prospective memory impairment in patients with breast cancer with different expression of hormone receptors, including the estrogen receptor (ER) and the progesterone receptor (PR). A total of 120 patients with breast cancer who underwent chemotherapy following surgery were divided into 2 groups. The A group included 60 patients with ER−/PR− status, and the B group included 60 patients with ER+/PR+ status. After 6 cycles of postoperative adjuvant chemotherapy, all patients were administered neuropsychological and prospective memory tests, such as the Mini-Mental State Examination (MMSE), verbal fluency test (VFT), and digit span test (DST), as well as examination of event-based prospective memory (EBPM) and time-based prospective memory (TBPM). As the neuropsychological background test results showed, there were no significant differences in MMSE, DST, and TBPM scores (*:P > 0.05) between patients with breast cancer in the ER−/PR− and ER+/PR+ groups, while the VFT and EBPM scores were significantly greater in patients with breast cancer with ER+/PR+ status than in those with ER−/PR− status (**: P < 0.01), indicating that patients with ER−/PR− status have significant impairment in EBPM, although not in TBPM. The results of the present study indicate that different hormone receptor expression in patients with breast cancer may be associated with heterogeneity of chemotherapy-induced prospective memory impairment.