Designing de novo: interdisciplinary debates in synthetic biology.
Designing de novo: interdisciplinary debates in synthetic biology.
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DOI：
10.1007/s11693-013-9106-6
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发表时间：
2013-06-01
期刊：
影响因子：
--
通讯作者：
Porcar, Manuel
中科院分区：
文献类型：
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作者：
Delgado, Ana;Porcar, Manuel
合成生物学通常被认为是一个充满希望的领域，它的目标是通过设计来产生新奇。最终的希望是生产出能够以可预测的方式执行新的和期望的功能的生命系统。然而，实现新奇的承诺并不是一件简单的事情。本文提供了一个概述，并探讨了现有的争论，从头设计生命系统的可能性，因为它们出现在合成生物学领域内的工程和生物学观点之间的跨学科会谈。为了扩大这种跨学科的辩论，我们包括社会科学和人文科学的观点，我们指出了该领域内分歧的一些基本来源。不同的观点并存，有时是有争议的紧张关系，但有时也以中间立场的形式指向一体化。由于该领域正在兴起，因此可能有多种选择。它们将为合成生物学的替代轨迹提供信息，并肯定会塑造其未来。什么方向是最好的，要以反射性和社会稳健的方式来决定。
Synthetic biology is often presented as a promissory field that ambitions to produce novelty by design. The ultimate promise is the production of living systems that will perform new and desired functions in predictable ways. Nevertheless, realizing promises of novelty has not proven to be a straightforward endeavour. This paper provides an overview of, and explores the existing debates on, the possibility of designing living systems de novo as they appear in interdisciplinary talks between engineering and biological views within the field of synthetic biology. To broaden such interdisciplinary debates, we include the views from the social sciences and the humanities and we point to some fundamental sources of disagreement within the field. Different views co-exist, sometimes as controversial tensions, but sometimes also pointing to integration in the form of intermediate positions. As the field is emerging, multiple choices are possible. They will inform alternative trajectories in synthetic biology and will certainly shape its future. What direction is best is to be decided in reflexive and socially robust ways.