A New "Lnc" to Brake Inflammation.
A New "Lnc" to Brake Inflammation.
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抑制炎症的新“Lnc”。
DOI：
10.1161/atvbaha.123.319444
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zhou,Jiliang
中科院分区：
文献类型：
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作者：
Long,Xiaochun;Miano,JosephM;Zhou,Jiliang
对血管壁的生物、化学和物理扰动引发炎症过程，最初旨在保持血管稳态。然而，如果炎症持续不减或在较长时间内反复爆发，则病理学恶化。例如，不受限制的高脂血症促进单核细胞粘附至内皮细胞，随后发生渗出，分化为巨噬细胞，从而清除浸润脂质，并形成泡沫细胞。慢性血管炎症加剧了这些早期的脂肪条纹，导致复杂的斑块，这些斑块可能破裂，导致心脏、大脑和四肢血管的灾难性闭塞。1编码抗炎基因的内源性蛋白2和复杂的3专门的前溶解脂质介质4平衡血管炎症。阐明炎症缓解机制以减轻血管疾病进展一直是主要关注领域。在过去的十年中，许多不编码蛋白质的基因已经成为炎症和炎症消退的关键微调器。5长链非编码RNA（LncRNA）是一类更不可预测的非编码基因，其功能范围从控制细胞核中的剪接、转录和结构构建到细胞质中的翻译、信号传导和转运。虽然有几十种LncRNA在刺激炎症中发挥作用，但相对较少的是对抗炎症过程。5–7
Biological, chemical, and physical perturbations to the vessel wall initiate inflammatory processes intended, initially, to preserve vascular homeostasis. However, if inflammation proceeds unabated or occurs repeatedly in bursts over an extended time period, pathology ensues. For example, unrestrained hyperlipidemia promotes monocyte adhesion to endothelial cells with subsequent diapedesis, differentiation into macrophages licensed to clear infiltrating lipids, and foam cell formation. Chronic vascular inflammation exacerbates these early fatty streaks leading to complicated plaques that may rupture causing catastrophic occlusion of vessels in the heart, brain, and extremities. 1 Endogenous protein encoding anti-inflammatory genes2 and the complicated3 specialized proresolving lipid mediators4 counterbalance vascular inflammation. Elucidating mechanisms of inflammatory resolution to mitigate vascular disease progression has been a major area of focus. Over the past decade, scores of genes that do not encode for proteins have emerged as critical fine tuners of inflammation and inflammatory resolution. 5 Long noncoding RNAs (LncRNAs) are among the more unpredictable class of noncoding genes with functions ranging from the control of splicing, transcription, and structural architecture in the nucleus to translation, signaling, and transport in the cytosol. Although dozens of LncRNAs have roles in stimulating inflammation, comparatively few counteract inflammatory processes. 5–7