Wireless Fast-Scan Cyclic Voltammetry to Monitor Adenosine in Patients With Essential Tremor During Deep Brain Stimulation
Wireless Fast-Scan Cyclic Voltammetry to Monitor Adenosine in Patients With Essential Tremor During Deep Brain Stimulation
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DOI：
10.1016/j.mayocp.2012.05.006
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发表时间：
2012-08-01
影响因子：
8.9
通讯作者：
Lee, Kendall H.
中科院分区：
文献类型：
--
作者：
Chang, Su-Youne;Kim, Inyong;Lee, Kendall H.
通过在激活神经刺激之前植入刺激电极，特发性震颤通常在深部脑刺激期间显著减少。这种意想不到的结果被称为小丘脑切除术效应，其机制被认为与靶向脑组织的微损伤有关，即丘脑切除术中组织消融的微观版本。另一种可能性是，植入电极会引起神经化学物质的立即释放。在此，我们报告了用实时快速扫描循环伏安法进行的实验，以量化在深部脑刺激下特发性震颤患者的神经递质浓度。结果表明，小丘脑切除效应伴随着局部神经化学变化，包括腺苷释放。(C) 2012梅奥医学教育和研究基金会，梅奥诊所项目，2012；87 (8): 760 - 765
Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release. (C) 2012 Mayo Foundation for Medical Education and Research Mayo Clin Proc. 2012;87(8):760-765