A disruption of colour priming following continuous theta burst transcranial magnetic stimulation.
A disruption of colour priming following continuous theta burst transcranial magnetic stimulation.
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连续 theta 爆发经颅磁刺激后颜色启动的中断。
DOI：
10.1016/j.cortex.2012.02.009
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Banissy MJ
中科院分区：
文献类型：
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作者：
Banissy MJ
已经确定，一个视觉属性（例如颜色、运动）的呈现可以提高在后续试验中检测到相同属性的可能性（Tulving和Schacter，1990）。越来越多的证据表明，这种效应是以自下而上的方式驱动的（Maljkovic和Nakayama，1994），这取决于功能特化的纹外区（沃尔什等人，2000; Campana等人，2002年; Kristjánsson等人，2005年、2007年）。例如，对猕猴区域V4和TEO的损伤消除了颜色并形成启动（沃尔什等人，2000年）。此外，在人类中，靶向V5/MT的经颅磁刺激（TMS）已经显示出消除运动启动（Campana等人，2002年）。然而，也有证据表明，相对较小的刺激操作可以改变启动似乎发生的水平（见Kristjánsson和Campana，2010）。例如，当使用与探针刺激相同类型的启动时，较低的视觉水平可以介导运动启动，而当启动和探针类型不同时，启动发生在较高水平（Campana等人，2008）。在此，我们试图建立连续θ脉冲TMS的效果（cTBS; Huang et al.，2005）靶向人左V4（Morita等人，2004），左V5/MT或顶点，对颜色的知觉启动。基于颜色启动是颜色选择性纹外区神经活动的结果这一假设，我们预期针对人类V4的cTBS会破坏颜色启动，但这不会在cTBS到达我们的主动对照位点（V5/MT和顶点）后发生。
It is well established that the presentation of one visual attribute (eg, colour, motion) can improve the likelihood of the same attribute being detected on a subsequent trial (Tulving and Schacter, 1990). There is growing evidence to suggest that this effect is driven in a bottom-up manner (Maljkovic and Nakayama, 1994), which is dependent upon functionally specialized extrastriate regions (Walsh et al., 2000; Campana et al., 2002; Kristjánsson et al., 2005, 2007). For example, lesions to macaque area V4 and TEO abolish colour and form priming (Walsh et al., 2000). Also, in humans, transcranial magnetic stimulation (TMS) targeted at V5/MT has been shown to abolish motion priming (Campana et al., 2002). However, there is also evidence that relatively minor manipulation of the stimuli can alter the level at which priming seems to occur (see Kristjánsson and Campana, 2010). For example, lower visual levels can mediate motion priming when a prime of the same type as the probe stimulus is used, whereas priming occurs at a higher level when the prime and probe differ in type (Campana et al., 2008).Here, we sought to establish the effects of continuous theta burst TMS (cTBS; Huang et al., 2005) targeted at human left V4 (Morita et al., 2004), left V5/MT or the vertex, on the perceptual priming of colour. Based on the assumption that colour priming is a consequence of neural activity in colour selective extrastriate regions, we expected that cTBS targeted at human V4 would disrupt colour priming, but that this would not occur following cTBS to our active control sites (V5/MT and the vertex).