New model of oropharyngeal candidiasis in mice
New model of oropharyngeal candidiasis in mice
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DOI：
10.1128/aac.45.11.3195-3197.2001
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发表时间：
2001-11-01
影响因子：
4.9
通讯作者：
Filler, SG
中科院分区：
文献类型：
--
作者：
Kamai, Y;Kubota, M;Filler, SG
我们建立了一个简单的口咽念珠菌病小鼠模型。小鼠用醋酸可的松免疫抑制，麻醉，然后通过舌下放置用白色念珠菌饱和的棉絮球接种2 h。一个长期的，可重复的感染诱导。该模型可用于抗真菌药物筛选或致病机理研究。
We established a straightforward murine model of oropharyngeal candidiasis. Mice were immunosuppressed with cortisone acetate, anesthetized, and then inoculated by placing cotton wool balls saturated with Candida albicans sublingually for 2 h. A prolonged, reproducible infection was induced. This model may be useful for antifungal screening or pathogenesis studies.