Microbiome engineering: engineered live biotherapeutic products for treating human disease.
Microbiome engineering: engineered live biotherapeutic products for treating human disease.
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DOI：
10.3389/fbioe.2022.1000873
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发表时间：
2022
影响因子：
5.7
通讯作者：
Barnes, Chris P.
中科院分区：
文献类型：
--
作者：
Rutter, Jack W.;Dekker, Linda;Owen, Kimberley A.;Barnes, Chris P.
人类微生物群与许多疾病状态有关，包括神经系统疾病、癌症和炎症性疾病。这种对人类健康潜在的巨大影响促进了微生物组工程方法的发展，该方法试图调整人类宿主微生物群系统的组成和功能以达到治疗目的。一种有前途的方法是使用经过修饰以执行治疗功能的工程微生物。这些产品中的大多数仅在实验室模型中进行了演示；然而，近年来，更多的概念已经进入转化阶段。这导致临床试验数量的增加，旨在评估这些治疗方法在人类中的安全性和有效性。在这篇综述中，我们重点介绍了其中一些微生物组工程临床研究的进展，重点是工程化的活生物治疗产品。
The human microbiota is implicated in many disease states, including neurological disorders, cancer, and inflammatory diseases. This potentially huge impact on human health has prompted the development of microbiome engineering methods, which attempt to adapt the composition and function of the human host-microbiota system for a therapeutic purpose. One promising method is the use of engineered microorganisms that have been modified to perform a therapeutic function. The majority of these products have only been demonstrated in laboratory models; however, in recent years more concepts have reached the translational stage. This has led to an increase in the number of clinical trials, which are designed to assess the safety and efficacy of these treatments in humans. Within this review, we highlight the progress of some of these microbiome engineering clinical studies, with a focus on engineered live biotherapeutic products.
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影响因子：
9
作者：
Coley, W B
通讯作者：
Coley, W B
影响因子：
--
作者：
Grigoryan, Zoya;Shen, Michael J;Bateman-House, Alison
通讯作者：
Bateman-House, Alison
DOI：
10.1093/synbio/ysac001
发表时间：
2021
期刊：
Synthetic biology (Oxford, England)
影响因子：
--
作者：
Brennan AM
通讯作者：
Brennan AM
影响因子：
28.1
作者：
Cubillos-Ruiz, Andres;Alcantar, Miguel A.;Collins, James J.
通讯作者：
Collins, James J.
影响因子：
4.6
作者：
Crowe JS;Roberts KJ;Carlton TM;Maggiore L;Cubitt MF;Clare S;Harcourt K;Reckless J;MacDonald TT;Ray KP;Vossenkämper A;West MR
通讯作者：
West MR