Novel mechanisms of tube-size regulation revealed by the Drosophila trachea.
Novel mechanisms of tube-size regulation revealed by the Drosophila trachea.
复制标题
果蝇气管揭示了管尺寸调节的新机制。
DOI：
10.1007/s00441-013-1673-z
复制
发表时间：
2013
影响因子：
3.6
通讯作者：
Jiang,Lan
中科院分区：
文献类型：
--
作者：
Zuo,Li;Iordanou,Ekaterini;Chandran,RachanaR;Jiang,Lan
管状器官（如肺、血管系统和肾脏）内各种管道的大小必须进行微调，以优化整个生物体内气体、营养物质、废物和细胞的输送。异常的管尺寸导致毁灭性的人类疾病，如多囊肾病，纤维囊性乳腺病，胰腺囊性肿瘤和甲状腺结节。然而，负责管尺寸监管的基本机制尚未完全理解。因此，没有有效的治疗方法可用于由管尺寸缺陷引起的疾病。近年来，果蝇尾管系统已成为研究尾管大小调节机制的一个很好的体内模型。在这里，我们讨论的作用，顶端管腔基质，细胞极性和信号通路在调节管大小inDrosophilophilia。以往对果蝇上皮细胞愈合系统的研究为上皮细胞管的形态发生提供了一般性的认识。调节果蝇管状器官大小的机制在哺乳动物的管状器官中可能是保守的。这些知识将极大地帮助我们理解脊椎动物的管状器官发生，并可能为治疗由管状缺陷引起的人类疾病开辟新的途径。
The size of various tubes within tubular organs such as the lung, vascular system and kidney must be finely tuned for the optimal delivery of gases, nutrients, waste and cells within the entire organism. Aberrant tube sizes lead to devastating human illnesses, such as polycystic kidney disease, fibrocystic breast disease, pancreatic cystic neoplasm and thyroid nodules. However, the underlying mechanisms that are responsible for tube-size regulation have yet to be fully understood. Therefore, no effective treatments are available for disorders caused by tube-size defects. Recently, theDrosophilatracheal system has emerged as an excellent in vivo model to explore the fundamental mechanisms of tube-size regulation. Here, we discuss the role of the apical luminal matrix, cell polarity and signaling pathways in regulating tube size inDrosophilatrachea. Previous studies of theDrosophilatracheal system have provided general insights into epithelial tube morphogenesis. Mechanisms that regulate tube size inDrosophilatrachea could be well conserved in mammalian tubular organs. This knowledge should greatly aid our understanding of tubular organogenesis in vertebrates and potentially lead to new avenues for the treatment of human disease caused by tube-size defects.