Cranial neural crest migration: new rules for an old road.
Cranial neural crest migration: new rules for an old road.
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DOI：
10.1016/j.ydbio.2010.04.010
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发表时间：
2010-08-15
影响因子：
2.7
通讯作者：
McLennan R
中科院分区：
文献类型：
--
作者：
Kulesa PM;Bailey CM;Kasemeier-Kulesa JC;McLennan R
神经嵴是更好地理解胚胎细胞迁移机制的优秀模型。细胞追踪研究表明，颅神经嵴细胞（CNCC）以头尾方式从背神经管中出现，并沿着典型的长距离迁移路线在空间上分布到头部和鳃弓的精确目标。尽管 CNCC 的迁移模式是精心设计和编程的入侵，但分子事件的底层编排尚不清楚。例如，目前尚不清楚单个 CNCC 如何对指导其方向选择的信号做出反应，以及 CNCC 组如何协调其交互以有序地到达目标。在这篇综述中，我们讨论了 CNCC 迁移模式的最新细胞和分子发现。我们重点关注 CNCC 遇到神经管附近的组织以及它们穿过不同的微环境并进入鳃弓时发生的事件。我们描述了从后脑、菱形 (r) 节段 r1-r7 出现的离散细胞迁移流的模式，以及协调定向迁移的信号。我们提出了一个模型，试图统一建立 CNCC 迁移模式的许多复杂事件，并基于该模型，我们整合了颅骨和躯干神经嵴发育之间的信息。
The neural crest serve as an excellent model to better understand mechanisms of embryonic cell migration. Cell tracing studies have shown that cranial neural crest cells (CNCCs) emerge from the dorsal neural tube in a rostrocaudal manner and are spatially distributed along stereotypical, long distance migratory routes to precise targets in the head and branchial arches. Although the CNCC migratory pattern is a beautifully choreographed and programmed invasion, the underlying orchestration of molecular events is not well known. For example, it is still unclear how single CNCCs react to signals that direct their choice of direction and how groups of CNCCs coordinate their interactions to arrive at a target in an ordered manner. In this review, we discuss recent cellular and molecular discoveries of the CNCC migratory pattern. We focus on events from the time when CNCCs encounter the tissue adjacent to the neural tube and their travel through different microenvironments and into the branchial arches. We describe the patterning of discrete cell migratory streams that emerge from the hindbrain, rhombomere (r) segments r1–r7, and the signals that coordinate directed migration. We propose a model that attempts to unify many complex events that establish the CNCC migratory pattern, and based on this model we integrate information between cranial and trunk neural crest development.