Tetranectin as a Potential Biomarker for Stable Coronary Artery Disease
Tetranectin as a Potential Biomarker for Stable Coronary Artery Disease
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四连蛋白作为稳定型冠状动脉疾病的潜在生物标志物
DOI：
10.1038/srep17632
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发表时间：
2015-12-01
影响因子：
4.6
通讯作者：
Jin, Wei
中科院分区：
文献类型：
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作者：
Chen, Yanjia;Han, Hui;Jin, Wei
这项横断面研究检验了以下假设：血清四连接素（TN）水平降低（一种纤维蛋白溶解和蛋白水解系统的调节剂）与CAD的存在和严重程度相关。我们进行了系统的血清学和免疫组织化学（IHC）分析，分别比较了冠心病患者和健康对照组血清和动脉标本中的TN水平。我们的研究结果表明，血清总氮水平显着低于冠心病患者比健康对照组。进一步分析表明，血清总氮水平与动脉病变支数相关.此外，多因素Logistic回归模型显示TN是与CAD存在相关的独立因素。此外，IHC分析显示，与健康对照组织相比，动脉粥样硬化动脉中TN表达显著更高。总之，我们的研究表明，血清总氮水平升高与稳定型CAD患者冠状动脉病变的存在和严重程度相关。
This cross-sectional study tested the hypothesis that decreased serum levels of tetranectin (TN), a regulator of the fibrinolysis and proteolytic system, is associated with the presence and severity of CAD. We conducted a systematic serological and immunohistochemical (IHC) analysis to respectively compare the TN levels in serum and artery samples in CAD patients and healthy controls. Our results showed that serum levels of TN were significantly lower in patients with CAD than in healthy controls. Further analysisviatrend tests revealed that serum TN levels correlated with the number of diseased arteries. Besides, the multivariate logistic regression model revealed TN as an independent factor associated with the presence of CAD. Additionally, IHC analysis showed that TN expression was significantly higher in atherosclerotic arteries as compared to healthy control tissues. In conclusion, our study suggests that increased serum TN level is associated with the presence and severity of diseased coronary arteries in patients with stable CAD.