Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity.
Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity.
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DOI：
10.1186/s10194-017-0748-8
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发表时间：
2017-12
期刊：
影响因子：
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通讯作者：
Bond DS
中科院分区：
文献类型：
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作者：
Galioto R;O'Leary KC;Thomas JG;Demos K;Lipton RB;Gunstad J;Pavlović JM;Roth J;Rathier L;Bond DS
疼痛灾难化 (PC) 与更严重和致残的偏头痛发作有关。然而，调节这种关系的因素尚不清楚。抑制控制 (IC) 失败或抑制自动或不适当反应的能力可能是此类因素之一，因为先前的研究表明非偏头痛样本中较高的 PC 与较低的 IC 之间存在关系，而研究表明偏头痛样本中的 IC 降低。因此，我们检查了较低的 IC 是否与增加的 PC 相互作用，以预测偏头痛的严重程度（通过疼痛强度、发作频率和持续时间来衡量）。寻求减肥和减轻偏头痛行为治疗的 18-50 岁 (M = 38.0 ± 1.2) 超重/肥胖和偏头痛女性 (n = 105) 完成了为期 28 天的基于智能手机的头痛日记，评估偏头痛的严重程度。然后，参与者完成了修改后的计算机化斯特鲁普任务，作为 IC 的测量以及 PC（疼痛灾难化量表 [PCS]）、焦虑和抑郁的自我报告测量。在控制年龄、体重指数 (BMI) 抑郁和焦虑后，使用线性回归来检查 PC 和 IC 与偏头痛严重程度指数的独立和联合关联。参与者的平均 BMI 为 35.1±±6.5 kg/m2，并报告 28 天内有 5.3±±2.6 次偏头痛发作（8.3±±4.4 偏头痛天），产生中度疼痛强度（10 中为 5.9±±1.4），持续时间为20.0 ± 14.2小时。调整协变量后，较高的 PCS 总分 (β = .241、SE = .14、p = .03) 和放大分量表 (β = .311、SE = .51、p < .01) 分数与较长的发作持续时间具有显着的独立相关性。 IC 与总 PCS (β = 1.106, SE = .001, p = .03)、沉思 (β = 1.098, SE = .001, p = .04) 和无助感 (β = 1.026, SE = .001, p = .04) 子量表分数可预测头痛疼痛强度，使得 PC 与疼痛强度之间的关联在 IC 水平较低时变得更加正相关。结果表明，较低的 IC 与较高的 PC（整体和特定子成分）相互作用，可预测偏头痛发作期间较高的疼痛强度。未来的研究需要确定改善 IC 的干预措施是否可以通过改善 PC 来减轻偏头痛发作的痛苦。
Pain catastrophizing (PC) is associated with more severe and disabling migraine attacks. However, factors that moderate this relationship are unknown. Failure of inhibitory control (IC), or the ability to suppress automatic or inappropriate responses, may be one such factor given previous research showing a relationship between higher PC and lower IC in non-migraine samples, and research showing reduced IC in migraine. Therefore, we examined whether lower IC interacts with increased PC to predict greater migraine severity as measured by pain intensity, attack frequency, and duration. Women (n = 105) aged 18–50 years old (M = 38.0 ± 1.2) with overweight/obesity and migraine who were seeking behavioral treatment for weight loss and migraine reduction completed a 28-day smartphone-based headache diary assessing migraine headache severity. Participants then completed a modified computerized Stroop task as a measure of IC and self-report measures of PC (Pain Catastrophizing Scale [PCS]), anxiety, and depression. Linear regression was used to examine independent and joint associations of PC and IC with indices of migraine severity after controlling for age, body mass index (BMI) depression, and anxiety. Participants on average had BMI of 35.1 ± 6.5 kg/m2and reported 5.3 ± 2.6 migraine attacks (8.3 ± 4.4 migraine days) over 28 days that produced moderate pain intensity (5.9 ± 1.4 out of 10) with duration of 20.0 ± 14.2 h. After adjusting for covariates, higher PCS total (β = .241, SE = .14, p = .03) and magnification subscale (β = .311, SE = .51, p < .01) scores were significant independent correlates of longer attack duration. IC interacted with total PCS (β = 1.106, SE = .001, p = .03) rumination (β = 1.098, SE = .001, p = .04), and helplessness (β = 1.026, SE = .001, p = .04) subscale scores to predict headache pain intensity, such that the association between PC and pain intensity became more positive at lower levels of IC. Results showed that lower IC interacted with higher PC, both overall and specific subcomponents, to predict higher pain intensity during migraine attacks. Future studies are needed to determine whether interventions to improve IC could lead to less painful migraine attacks via improvements in PC.