Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis
Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis
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DOI：
10.1038/s41422-019-0177-0
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Wang Ping
中科院分区：
文献类型：
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作者：
Wu Zhiqiang;Weng Linjun;Zhang Tengbo;Tian Hongling;Fang Lan;Teng Hongqi;Zhang Wen;Gao Jing;Hao Yun;Li Yaxu;Zhou Hu;Wang Ping
Dear Editor,Cancer cells often upregulate the expression of ligands for the inhibitory immune checkpoints receptor to escape anti-tumor immunity1.Targeting inhibitory immune checkpoints has become one of the most promising anticancer therapeutic inventions.Infiltration of myeloid cells,especially phagocytic cells,to tumors is often associated with chemotherapy resistance and progression of various cancer types.Phagocytosis of cancer cells is the major mechanism for these myeloid cells-mediated antitumor activity.However,many types of cancer cells express high level of ‘don’t eat me’ signals on the cell surface to escape the phagocytic cellsmediated antitumor immunity.
