Translocation and action of polypeptide hormones within the nucleus. Relevance to lactogenic transduction.
Translocation and action of polypeptide hormones within the nucleus. Relevance to lactogenic transduction.
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细胞核内多肽激素的易位和作用。
DOI：
10.1007/0-306-46832-8_9
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发表时间：
2000
影响因子：
--
通讯作者：
Rycyzyn,MA
中科院分区：
文献类型：
--
作者：
Clevenger,CV;Rycyzyn,MA
跨膜受体介导的多肽激素在细胞表面的作用已得到广泛认可。然而，越来越多的证据也表明，此类激素也会在细胞核内移位并直接发挥作用。本章将概述催乳素（PRL）这样一个例子的作用的已知信息，从其在细胞表面的经典作用到其在细胞核内的新功能。
The action of polypeptide hormones at the cell surface as mediated by transmembrane receptors is well recognised. However, a growing body of evidence also indicates that such hormones are also translocated and act directly within the cell nucleus. This chapter will overview what is known of the action of one such example, namely prolactin (PRL), from its classic action at the cell surface, to its novel function within the nucleus.