Regular exercise prevents high-sucrose diet-induced fatty liver via improvement of hepatic lipid metabolism
Regular exercise prevents high-sucrose diet-induced fatty liver via improvement of hepatic lipid metabolism
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DOI：
10.1016/j.bbrc.2011.08.097
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发表时间：
2011-09-23
影响因子：
3.1
通讯作者：
Yoshikawa, Toshikazu
中科院分区：
文献类型：
--
作者：
Aoi, Wataru;Naito, Yuji;Yoshikawa, Toshikazu
脂肪肝被称为非酒精性脂肪肝疾病的初始阶段。流行病学研究表明，定期运动可以防止肝脏脂质堆积，但其潜在机制尚不清楚。本研究的目的是探讨运动对与肝脏脂质代谢相关的脂肪肝的影响。 KK/Ta 小鼠（6 周龄）分为静坐组和运动组，并与静坐 Balb/c 小鼠进行比较。所有小鼠均接受高蔗糖饮食 12 周。运动组KK/Ta小鼠以20 m/min的速度进行跑步机跑步运动30 min(每周3次)。十二周的定期运动抑制了肝脏中脂质的积累，同时降低了血浆中脂质的水平。肉碱棕榈酰转移酶 II、酰基辅酶 A 脱氢酶和三功能酶（肝脏中脂肪酸氧化的限速酶）的水平会因运动而升高。此外，运动会降低脂肪酸合酶（一种关键的脂肪生成酶）的表达。此外，定期运动会降低肝脏中肝纤维化标志物热休克蛋白47的表达。我们的结果表明，定期运动可以通过改善肝脏脂质代谢来预防脂肪肝。 (C) 2011 Elsevier Inc. 保留所有权利。
Fatty liver is known as the initial stage in nonalcoholic fatty liver disease. Epidemiological studies have shown that regular exercise prevents accumulation of hepatic lipids, although the underlying mechanism is unclear. The purpose of this study was to investigate the effect of exercise on fatty liver associated with hepatic lipid metabolism. KK/Ta mice (6 weeks old) were divided into sedentary and exercise groups and compared with sedentary Balb/c mice. All the mice were fed a high-sucrose diet for 12 weeks. The KK/Ta mice in the exercise group performed a treadmill running exercise at 20 m/min for 30 min (3 times per week). Twelve weeks of regular exercise suppressed the accumulation of lipid in the liver, along with reduction in the level of lipid in the plasma. The levels of carnitine palmitoyl transferase II, acyl-coenzyme A dehydrogenase, and trifunctional enzyme, which are rate-limiting enzymes in fatty acid oxidation in the liver, were elevated by exercise. In addition, the expression of fatty acid synthase, a key lipogenetic enzyme, was reduced by exercise. Furthermore, regular exercise decreased the expression of heat shock protein 47, a marker of hepatic fibrosis, in the liver. Our results suggest that regular exercise prevents fatty liver via improvement of hepatic lipid metabolism. (C) 2011 Elsevier Inc. All rights reserved.