Higher Adolescent Body Mass Index Is Associated with Lower Regional Gray and White Matter Volumes Lower Levels of Positive Emotionality
Higher Adolescent Body Mass Index Is Associated with Lower Regional Gray and White Matter Volumes Lower Levels of Positive Emotionality
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DOI：
10.3389/fnins.2016.00413
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发表时间：
2016-09-08
影响因子：
4.3
通讯作者：
Luciana, Monica
中科院分区：
文献类型：
--
作者：
Kennedy, James T.;Collins, Paul F.;Luciana, Monica
青少年肥胖与晚年发展成严重健康风险的机会增加有关。确定与肥胖增加相关的神经生物学和个性因素，对于理解是什么驱动了导致肥胖的适应不良、消耗性行为和运动行为非常重要。以前的研究主要集中在成年人身上，很少有关于肥胖、大脑结构和个性之间相互作用的研究结果发表。在这项研究中，基于体素的形态计量学(VBM)被用来确定灰质和白质体积与肥胖增加之间的关系，通过身体质量指数百分位数(BMI%)来衡量，137名青少年(年龄范围：920岁，BMI%范围：5.1699.56)。然后，灰质和白质体积以及BMI%的变化与多维人格问卷(MPQ)中个性测量的个体差异有关。在控制年龄和其他协变量后，BMI%与双侧尾状核(右：部分r=-0.338，左：r=-0.404)、内侧前额叶皮质(部分r=-0.339)、扣带前皮质(部分r=-0.312)、双侧额极(右：部分r=-0.368，左：r=-0.316)、钩体(部分r=-0.475)的灰质体积以及双侧内囊前肢的白质体积(右：部分r=-0.34，左侧：R=-0.386)，延伸至左侧额中回下白质。老年积极情绪性与BMI%呈负相关(偏r=-0.384)。右钩PEM-AG与灰质体积呈正相关(偏r=0.329)。这些结果表明，青少年肥胖程度越高，与奖赏相关人格领域的特质水平越低，与奖赏处理、控制和感觉整合相关的大脑区域的结构变化也就越多。
Adolescent obesity is associated with an increased chance of developing serious health risks later in life. Identifying the neurobiological and personality factors related to increases in adiposity is important to understanding what drives maladaptive consummatory and exercise behaviors that result in obesity. Previous research has largely focused on adults with few findings published on interactions among adiposity, brain structure, and personality. In this study, Voxel Based Morphometry (VBM) was used to identify associations between gray and white matter volumes and increasing adiposity, as measured by Body Mass Index percentile (BMI%), in 137 adolescents (age range: 920 years, BMI% range: 5.1699.56). Variations in gray and white matter volume and BMI% were then linked to individual differences in personality measures from the Multidimensional Personality Questionnaire (MPQ). After controlling for age and other covariates, BMI% correlated negatively with gray matter volume in the bilateral caudate (right: partial r = -0.338, left: r = -0.404), medial prefrontal cortex (partial r = -0.339), anterior cingulate (partial r = -0.312), bilateral frontal pole (right: partial r = -0.368, left: r = -0.316), and uncus (partial r = -0.475) as well as white matter volume bilaterally in the anterior limb of the internal capsule (right: partial r = -0.34, left: r = -0.386), extending to the left middle frontal subgyral white matter. Agentic Positive Emotionality (PEM-AG) was correlated negatively with BMI% (partial r = -0.384). PEM-AG was correlated positively with gray matter volume in the right uncus (partial r = 0.329). These results suggest that higher levels of adiposity in adolescents are associated with lower trait levels in reward-related personality domains, as well as structural variations in brain regions associated with reward processing, control, and sensory integration.