Interrelations between brachial endothelial function and carotid intima-media thickness in young adults -: The Cardiovascular Risk in Young Finns Study
Interrelations between brachial endothelial function and carotid intima-media thickness in young adults -: The Cardiovascular Risk in Young Finns Study
复制标题
DOI：
10.1161/01.cir.0000147540.88559.00
复制
发表时间：
2004-11-02
期刊：
影响因子：
37.8
通讯作者：
Raitakari, OT
中科院分区：
文献类型：
--
作者：
Juonala, M;Viikari, JSA;Raitakari, OT
背景-内皮血管舒张功能障碍和颈动脉内膜中层增厚（IMT）是亚临床心血管疾病的两个指标。我们研究了他们的相关性和相互作用的危险因素在一个大的，以社区为基础的队列的年轻adultes.Methods和结果-作为纵向心血管风险的一部分，在年轻的芬兰人的研究，我们测量内皮依赖性肱动脉血流介导的扩张（FMD）和颈动脉IMT超声在2109健康成人年龄在24至39岁。在校正了年龄、性别、肱动脉大小和几个风险变量的多变量模型中，FMD与IMT呈负相关（P小于或等于0.001）。年龄和性别特异性FMD值在极端十分位数的受试者被分为FMD反应受损组（n = 204，FMD = 1.1 +/-1.4%，平均值+/- SD）和FMD反应增强组（n = 204，FMD = 16.3 +/- 2.9%）。在FMD反应受损的受试者中，危险因素的数量与IMT增加相关（P < 0.05），但在FMD反应增强的受试者中，危险因素的数量与IMT增加无关（P > 0.2）。在有内皮功能障碍证据的受试者中，年轻成人中危险因素的数量与IMT增加相关，但在内皮功能保留的受试者中不相关。这些观察结果表明，内皮功能障碍是动脉粥样硬化的早期事件，全身内皮功能的状态可能会改变危险因素和动脉粥样硬化之间的关联。
Background - Endothelial vasodilator dysfunction and carotid intima-media thickening (IMT) are 2 indicators of subclinical cardiovascular disease. We examined their correlation and interaction with risk factors in a large, community-based cohort of young adults.Methods and Results - As part of the longitudinal Cardiovascular Risk in Young Finns Study, we measured endothelium-dependent brachial artery flow - mediated dilatation (FMD) and carotid artery IMT by ultrasound in 2109 healthy adults aged 24 to 39 years. FMD was inversely associated with IMT ( P less than or equal to 0.001) in a multivariate model adjusted for age, sex, brachial vessel size, and several risk variables. The subjects with age- and sex-specific FMD values in the extreme deciles were classified into groups of impaired ( n = 204, FMD = 1.1 +/- 1.4%, mean +/- SD) and enhanced ( n = 204, FMD = 16.3 +/- 2.9%) FMD response. The number of risk factors was correlated with increased IMT in subjects with an impaired FMD response ( P < 0.05) but not in subjects with an enhanced FMD response ( P > 0.2).Conclusions - Brachial FMD is inversely associated with carotid IMT. The number of risk factors in young adults is correlated with increased IMT in subjects with evidence of endothelial dysfunction, but not in subjects with preserved endothelial function. These observations suggest that endothelial dysfunction is an early event in atherosclerosis and that the status of systemic endothelial function may modify the association between risk factors and atherosclerosis.