Uptake of Gd-EOB-DTPA by hepatocellular carcinoma: Radiologic-pathologic correlation with special reference to bile production
Uptake of Gd-EOB-DTPA by hepatocellular carcinoma: Radiologic-pathologic correlation with special reference to bile production
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DOI：
10.1016/j.ejrad.2010.10.032
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发表时间：
2011-12-01
影响因子：
3.3
通讯作者：
Honda, Hiroshi
中科院分区：
文献类型：
--
作者：
Asayama, Yoshiki;Tajima, Tsuyoshi;Honda, Hiroshi
目的：本研究旨在揭示肝细胞癌（HCC）肝胆期肿瘤内Gd-EOB-DTPA摄取与病理学特征的关系。材料与方法：56例经病理证实的HCC结节60个，均行动态MRI检查。在注射Gd-EOB-DTPA前和注射Gd-EOB-DTPA后20 min（肝胆期）进行T1加权三维梯度回波序列。Gd-EOB-DTPA摄取定义为与造影前扫描相比，肝胆相信号强度增加。所有手术标本均用福尔马林固定，然后数码拍照。结果：22个结节表现为Gd-EOB-DTPA摄取，其中22个结节表现为Gd-EOB-DTPA摄取，其余结节表现为Gd-EOB-DTPA摄取。组织学检查结果表明，26个结节含有绿色区域。HCC显示Gd-EOB-DTPA摄取与绿色区域的存在之间存在显著相关性（p < 0.001）。在逐个结节的基础上，22个病灶中只有12个（54.5%）的Gd-EOB DTPA吸收面积的三分之二以上与绿色部分一致。结论：Gd-EOB-DTPA摄取区与绿区并不完全一致，但Gd-EOB-DTPA摄取区与绿色区有明显相关性。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Purpose: The aim of this study was to reveal the relationship between intratumoral uptake of gadoliniumethoxylbenzyldiethylenetriaminepentaacetic acid (Gd-EOB-DTPA) of hepatocellular carcinoma (HCC) in the hepatobiliary phase and pathological features.Materials and methods: Sixty HCC nodules were confirmed at pathology in 56 patients who had undergone dynamic MRI. T1-weighted 3D gradient echo sequences before and 20 min (hepatobiliary phase) after the injection of Gd-EOB-DTPA were performed. Uptake of Gd-EOB-DTPA was defined as an increase in signal intensity in the hepatobiliary phase compared with the precontrast scan. All surgical specimens were fixed with formalin and then digitally photographed. The relationship between Gd-EOB-DTPA uptake and histological findings, including a macroscopic greenish area, was examined.Results: MR images showed uptake of Gd-EOB-DTPA in twenty-two nodules. Histological findings indicated twenty-six nodules contained a greenish area. There is a significant correlation between HCC showing Gd-EOB-DTPA uptake and the presence of a greenish area (p < 0.001). On a nodule-by-nodule basis, more than two-thirds of the area of Gd-EOB DTPA uptake coincides with the greenish part in only 12 of 22 lesions (54.5%). More than two-thirds of the greenish area coincided with that of Gd-EOB-DTPA uptake in only 10 of 26 cases (38.5%).Conclusion: The area of Gd-EOB-DTPA uptake does not always match the greenish part, but HCC with uptake of Gd-EOB-DTPA significantly correlated with green HCC. (C) 2010 Elsevier Ireland Ltd. All rights reserved.